2008年桂林市城乡居民乙型肝炎病毒感染状况调查  

Survey on Hepatitis B Virus Infection among Urban and Rural Residents in Guilin City in 2008

作　　者：张振开 汤杰[1] 唐国荣[1] 张建新[1] 黄群雁 李坚龙 

机构地区：[1]桂林市疾病预防控制中心,广西桂林541001

出　　处：《预防医学论坛》2010年第7期590-592,共3页Preventive Medicine Tribune

摘　　要：[目的]了解桂林市居民乙型肝炎病毒（HBV）感染状况，评价1992年桂林市乙肝疫苗纳入儿童计划免疫管理和2002年实施适龄儿童乙肝疫苗免费接种的效果。[方法]2008年9月，在桂林市城乡。随机抽取2个城市社区和1个农村自然村，以家庭为单位每隔1户抽取1户，对所抽家庭中1～59岁人群和全部1～4岁儿童进行调查，采集静脉血检测HBV感染的5项指标。[结果]调查944人，HBsAg阳性率为5．19％，抗-HBs阳性率为67．27％，抗-HBe阳性率为3．60％，抗-HBc阳性率为27．33％，5项指标均阴性的占23．83％。HBsAg阳性率，男性与女性分别为3．84％、6．13％（P〉0．05）；1～4岁最低，不同年龄组的差异有统计学意义（Pdo．01）；农民和工人最高，不同职业的差异有统计学意义（P〈0．01）；接种过与未接种过乙肝疫苗者分别为2．00％、13．96％（P〈0．01）。抗-HBs阳性率，男性、女性分别为64．35％、69．31％（P〉0．05）；l～4岁最高，不同年龄组的差异有统计学意义（P〈0．01）；学龄前儿童、干部最高，不同职业的差异有统计学意义（P〈0．01）；接种过与未接种过乙肝疫苗者分别为72．29％、59．01％（P〈0．01）。[结论]桂林市城乡居民HBsAg阳性率较低，乙肝疫苗纳入儿童计划免疫管理和适龄儿童免费接种可以提高人群对HBV的免疫水平。[Objective]To understand the current status of hepatitis B virus infection among residents in Guilin city and evaluate the effect of immunization with hepatitis B vaccine since the implementation of the Expanded Program on Immunization（EPI）in 1992 and the implementation of free immunization of hepatitis B vaccine in 2002. [Methods]Cluster random sampling method was used to select 2 communities and 1 village as survey ob）ect in Guilin city. Vein blood samples were collected from all people aged 1-59 years in families from 2 selected communities and 1 village and the Case Survey Form was completed. HBsAg,anti-HBs, HBeAg, anti-HBe and anti-HBc were tested with ELISA reagents. [Results]The total 944 serum samples were tested, the positive rates of HBsAg and anti-HBs were 5.19% and 67.27%, respectively. The rate of all of 5 hepatitis virus B markers negative was 23. 83%. The HBsAg positive rates of male and female were 3.84% and 6.13% respectively（ P 〈0.05）. There was no significant difference of the HBsAg positive rate among different age groups and occupational groups（all P 〈0.01） ,the lowest rate was 0. 55% for I-years old group,and the top two places were doctor（17.24 %） and farmer（11. 95 %）. The HBsAg positive rates of the people vaccinated hepatitis B vaccine and not vaccinated were 2.00% and 13.96% respectively（ P 〈0.01）. The HBsb positive rates of male and female were 64.35 % and 69.31 % respectively（ P 〈0.05） ;There was no significant difference of the HBsb positive rate among different age groups and occupational groups（all P 〈0.01）, 1-years old group was the highest,and the top two places were preschool children and cadre. The HBsb positive rate of the people vaccinated hepatitis B vaccine and not vaccinated were 72.29% and 59.01 % respectively（ P 〈0.01）. [Conclusion]The infection rate of HBV is low in Guilin city. The strategy for hepatitis B vaccine immunization implemented is effective and successful in the control of hepatitis B.

关 键 词：乙型病毒性肝炎 乙肝病毒 感染 乙肝疫苗 接种 效果 

分 类 号：R512.62[医药卫生—内科学]