微生物源抗菌肽研究概况  

A Review of Antibacterial Peptides Produced by Microorganism

作　　者：陈琛[1] 

机构地区：[1]陕西理工学院陕西省资源生物重点实验室,汉中723000

出　　处：《生物技术通报》2010年第7期59-63,共5页Biotechnology Bulletin

基　　金：陕西省教育厅科学研究计划项目(09JK373);陕西理工学院引进人才科研启动项目(SLGQD0742)

摘　　要：抗菌肽是广泛存在于生物体内的一种小分子多肽,具有分子量小、高效、稳定、作用机制独特和不易产生耐药性等特点,对细菌、真菌、寄生虫、病毒以及肿瘤细胞均有抑制作用。介绍了微生物来源,尤其是细菌源抗菌肽的结构特点、生物活性、作用机制及其在感染性疾病中的应用情况。Antibacterial peptides, a cluster of small peptides secreted by the majority of creatures, have been demonstrated with activity against a wide range of microorganisms including bacteria, protozoa, yeast, fungi, viruses and even tumor cells. These active polypeptides have characteristics of small molecular mass, high efficacy, stability, particular antibacterial mechanism and little drug resist- ance. This review outlines some antibacterial peptides of microorganism, especially antibacterial peptides of bacteria,their structure,various functions and mechanisms of bactericidal activity, and also their use in treatment of some infectious diseases.

关 键 词：抗菌肽 活性 细菌 抗菌机理 

分 类 号：Q939.9[生物学—微生物学]