杏仁内侧核注射AVP和AVPMcAb对家兔ET性发热效应的影响  

THE EFFECT OF MICROINJECTION OF AVP AND AVPMcAb INTO MEDIAL AMYGDALOID NUCLEUS ON ENDOTOXIN INDUCED FEVER IN RABBITS

作　　者：杨永录[1,2] 王先鸣 石胜刚[1,2] 范华军 

机构地区：[1]解放军兰州医学高等专科学校生理教研室 [2]甘肃省人民医院

出　　处：《中国应用生理学杂志》1999年第1期62-65,共4页Chinese Journal of Applied Physiology

摘　　要：目的和方法：在大脑杏仁内侧核微量注射精氨酸加压素（ＡＶＰ）和精氨酸加压素单克隆抗体（ＡＶＰＭｃＡｂ），观察其对家兔内毒素（ＥＴ）性发热效应以及视前区一下丘脑前部（ＰＯＡＨ）温敏神经元放电活动的影响。结果：①杏仁内侧核微量注射ＡＶＰ能明显抑制家兔ＥＴ性发热效应，注射ＡＶＰＭｃＡｂ能明显易化家兔ＥＴ性发热效应；②杏仁外侧核分别注射ＡＶＰ和ＡＶＰＭｃＡｂ则对家兔ＥＴ性发热效应无明显影响；③杏仁内侧核分别注射ＡＶＰ和ＡＶＰＭｃＡｂ后ＰＯＡＨ热敏神经元和冷敏神经元放电活动均无明显变化。结论：家兔杏仁内侧核也是ＡＶＰ抗热效应的一个重要的作用部位。Aim and Methods:To investigate the effects of microinjection of arginine vasopressin (AVP) and arginine vasopressin monoclonal antibody(AVPMcAb) into the medial amygdaloid nucleus(AME) on endotoxin induced fever and discharge activity of temperature sensitive neurons in preoptic anterior hypothalamus(PO AH) of rabbit.Results: 1.Injection of AVP into AME markedly suppressed endotoxin induced fever. Injection of AVPMcAb into AME markedly augmented and prolonged fever responses. 2.Injection of AVP or AVPMcAb alone into lateral amygdaloid nucleus (AL) did not influence febrile responses. 3.Injection of AVP or AVPMcAb alone into AME did not influence the firing rate of PO AH warm sensitive neurons and cold sensitive neurons. Conclusion: AVP might act within the AME to evoke antipyresis, but antipyretic mechanism of injection AVP into AME may not alike with injection of AVP into the septal area.

关 键 词：精氨酸加压素 杏仁内侧核 抗热作用 

分 类 号：R338.26[医药卫生—人体生理学]