印迹基因及其对胚胎发育的调控  

Imprinted Genes and Embryos.

作　　者：李宏军[1,2] 郭应禄[1,2] 张志文[1,2] 

机构地区：[1]北京医科大学第一医院泌尿外科 [2]北京医科大学生理学系

出　　处：《生物化学与生物物理进展》1999年第1期19-22,共4页Progress In Biochemistry and Biophysics

摘　　要：某个基因位点呈单等位基因表达，且通过某种基因修饰作用来特异地抑制另一等位基因的表达，将这一基因称为印迹基因，它是等位基因排斥作用的一种特殊形式．多数印迹基因与胚胎发育有关，可以调节胚胎的生长、发育及新生儿的生长，印迹功能的紊乱可以导致多种发育异常及死胎．印迹基因的形成、特异识别及印迹性表达缺陷的机制还不清楚．Some genes express only one allelic gene and the another allelic gene is specifically inhibited through some kinds of gene modification. Those genes are called imprinted genes, and they are a unique model of allelic exclusion. Most of imprinted genes participate in regulating development and differentiation of embryo and newborn infant, and disorder of imprinting function may results in many kinds of abnormal development and stilbirth. The mechanisms for the formation of imprinted genes, specific recognization and the defect of imprinting function are still not very clear.

关 键 词：印迹基因 胚胎 生长发育 调节 

分 类 号：Q954.4[生物学—动物学] Q344.14