CAAT区/增强子结合蛋白(C/EBP)的结构与功能  

The Function and Structure of CAAT/enhancer Binding Protein (C/EBP).

作　　者：杨根焰[1] 张永莲[1] 

机构地区：[1]中国科学院上海生物化学研究所

出　　处：《生物化学与生物物理进展》1999年第1期26-30,共5页Progress In Biochemistry and Biophysics

摘　　要：Ｃ／ＥＢＰｓ是一组耐热的转录调控因子．其作用范围广泛，既参与正常的生理代谢过程，又与多种疾病的发生和发展相关；其作用方式多样，对转录的调控既有正效应又有负作用．Ｃ／ＥＢＰｓ的这种功能多样性是与其结构的特征性相联系的，它们属于ｂＺＩＰ蛋白家族．自身或与其他异构体形成蕴含着不同调控信息的同源或异源二聚体，并且能与多种蛋白质因子协同作用，决定Ｃ／ＥＢＰｓ发挥作用的方式和细胞特异性．C/EBPs are a group of heat stable transcription factors which function extensively. They not only involved in normal process of physiological metabolism but also are related to the occurrence and development of many kinds of disorders . C/EBPs have multiple modes in which they act as activator or inhibitor in regulating transcription . All these various functions of C/EBPs are related to their special structures that characterize the members of bZIP family.With themselves or other isoforms, C/EBPs can form homodimers or heterodimers that contain different regulational informations .Furthermore, they can interfere with a wide variety of protein factors, thus the mode and specificity of the functions of C/EBPs are determined .

关 键 词：C/EBPs 转录调控因子 bZIP蛋白 

分 类 号：Q513[生物学—生物化学] Q756