7-氨基庚酸盐酸盐的合成  

Synthesis of 7-Amino-heptanoic Acid Hydrochloride

作　　者：徐娟娟[1] 张镖[1] 李小珠[1] 陈家树[2] 

机构地区：[1]中山大学新华学院,广东广州510520 [2]中山大学医学院,广东广州510080

出　　处：《现代食品科技》2010年第6期598-599,共2页Modern Food Science and Technology

摘　　要：研究了7-氨基庚酸盐酸盐的合成方法。采用1,5-二溴戊烷依次与邻苯二甲酰亚胺化钾、丙二酸二乙酯发生亲核取代后得到2-(5-邻苯二甲酰亚胺基)戊基丙二酸二乙酯,最后在盐酸中水解、脱羧得到产物7-氨基庚酸盐酸盐。结果表明,7-氨基庚酸盐酸盐的总收率55%,产物经1HMNR(核磁共振氢谱)、LC-ELSD-UV-DAD-MS(配ELSD、UV、DAD、MS检测器)表征,符合结构特征。说明本方法所涉及反应步骤简单、操作简便。A novel route for 7-Amino-heptanoic acid hydrochloride preparation was developed in this paper by two step of nucleophilic substitution of 1,5-Dibromopentane with potassium phthalimide and diethyl malonate to give N-（5-Bromopentyl）phthalimide.The ester was converted to 7-Amino-heptanoic acid hydrochloride via hydrolyzation and decarboxylation.The total yield of 7-Amino-heptanoic acid hydrochloride was 55%.Structures of the products were confirmed by 1HNMR,LC-ELSD-UV-DAD-MS.The procedure was simple and convenient.

关 键 词：7-氨基庚酸盐酸盐 噻萘普汀 中间体 合成 

分 类 号：TQ226[化学工程—有机化工]