γ-氨基丁酸受体的反应动力学及其功能意义  

Response Kinetics of GABA Receptors and Their Functional Significance

作　　者：韩明虎[1] 沈颖[1] 杨雄里[1] 

机构地区：[1]中国科学院上海生理研究所

出　　处：《生理科学进展》1999年第1期10-16,共7页Progress in Physiological Sciences

摘　　要：γ氨基丁酸（ＧＡＢＡ）受体的反应动力学（激活、失敏和失活）是否在快速抑制性突触传递中起作用及怎样发挥作用是一个重要问题。随着分子生物学的发展、膜片钳技术及快速施药系统的应用，对ＧＡＢＡ受体的反应动力学的结构基础、单通道水平的发生机制及其功能意义等开始形成较全面的认识，揭示了其反应动力学在调节抑制性突触后电流（ＩＰＳＣ）中的关键作用及在快速抑制性突触传递中的重要意义。It is an important issue whether and how the response kinetics, including activation, desensitization and deactivation, of γ aminobutyric acid (GABA) receptors plays roles in rapid inhibitory postsynaptic transmission. With the development of molecular biology, and the use of patch clamp techniques and rapid solution changers, the structural basis, underlying mechanisms at single channel level and functional roles of the characteristics of GABA receptors have been fully explored. It is revealed that the response kinetics of GABA receptors plays a crucial role in modulating inhibitory postsynaptic currents and has a great importance for rapid inhibitory synaptic transmission.

关 键 词：Γ-氨基丁酸 受体 激活 失敏 神经系统 

分 类 号：Q954.67[生物学—动物学]