2-脱氧-D-葡萄糖的合成  

Synthesis of 2-deoxy-D-glucose

作　　者：徐淑周[1] 辛鹏[1] 陈锦春[1] 

机构地区：[1]烟台大学化学生物理工学院,山东烟台264005

出　　处：《应用化工》2010年第6期946-948,共3页Applied Chemical Industry

基　　金：烟台大学博士科研启动基金项目(HY07B30)

摘　　要：以无水葡萄糖为原料,通过乙酸酐保护、HBr溴代、锌粉还原、脱保护和酸水解5步反应合成了2-脱氧-D-葡萄糖,总收率为30%,其结构经过核磁共振谱图分析验证。该合成新方法与传统方法相比,避免了催化加氢步骤,缩短了总反应时间,提高了总产率,减少生产成本,简化工艺操作,适宜工业化规模生产。2-Deoxy-D-glucose was synthesized by using D-glucose as initial raw material and by the means of five-step reactions： acetic anhydride protection,bromination of hydrogen bromide,zinc reduction,de-protection and acid hydrolysis.The total yield was 30%,and the structure was confirmed by analysis of 1H NMR.Compared with conventional methods,the new synthetic method was without catalytic hydrogenation and shortened the total reaction time,increased the yield,decreased production costs,and was suitable for industrial production.

关 键 词：无水葡萄糖 2-脱氧-D-葡萄糖 合成 

分 类 号：TQ463[化学工程—制药化工]