温法干预治疗慢性乙型重型肝炎阳黄湿热内蕴(湿重于热)证的临床疗效与安全性研究  

Efficacy and safety of Ganluxiaodudan (TCM decoction) treatment in patients with chronic severe hepatitis B

作　　者：孙克伟[1] 龚磊[1] 陈斌[1] 黄裕红[1] 伍玉南[1] 阳航[1] 朱文芳[1] 张涛[1] 彭建平[1] 陈兰玲[1] 

机构地区：[1]湖南中医药大学第一附属医院传染病科,湖南省中医药管理局重型肝炎证治研究室,湖南长沙410007

出　　处：《中西医结合肝病杂志》2010年第3期135-137,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：国家科技重大专项"十一五"课题"慢性重型肝炎证候规律及中西医结合治疗方案研究"(No.2008ZX1005-007)资助

摘　　要：目的:比较清热利湿法加与不加温阳健脾药物治疗慢性重型肝炎(阳黄、湿重于热型)的疗效。方法:采用随机、对照方法,将60例中医辨证为湿重于热的慢性重型肝炎分为两组,分别给予甘露消毒丹(非温法干预组)和甘露消毒丹加附片、白术(温法干预组)治疗。结果:治疗4周,温法干预组和非温法干预组有效率分别为93.1%和72.41%。两组患者的TBil均有明显下降,温法干预组的下降幅度较非温法干预组明显,治疗前后差值分别为(228.62±89.18)和(176.70±97.94)μmol/L,两组比较,P<0.05。PTA水平都有不同程度的升高,温法干预组PTA水平上升的幅度大于非温法干预组,上升幅度均数比较,P<0.05。未发现温法干预组患者出现感染、出血及黄疸加重等不良反应。结论:清热利湿法加用附片、白术可提高慢性重型肝炎湿重于热证的疗效,且安全性良好。Objective：To observe the efficacy and safety of TCM decoction Ganluxiaodudan（GD） and Ganluxiaodudan plus Monkshood and Atractylodes（GDp） treatment in patients with chronic severe hepatitis B（CSHB）.Methods：Sixty patients with CSHB were randomly divided into two groups,one received GD,another GDp,for 4 weeks.Level of serum bilirubin,PTA and adverse events were observed.Results：The efficient was 93.1%（27/29）,72.41%（21/29） in group GD and GDp respectively.Level of serum bilirubin was significantly lower in both groups,but the descending extent in GDp was greater,compared with GD（228.62±89.18） and （176.70±97.94）μmol/L,respectively.The cases with infection were 7 and 3 in GD and GDp respectively.Conclusion：Ganluxiaodudan plus Monkshood and Atractylodes treatment is efficacy and safety in patients with chronic severe hepatitis B.

关 键 词：重型肝炎 乙型 慢性 甘露消毒丹/治疗应用 附片/治疗应用 白术/治疗应用 

分 类 号：R259[医药卫生—中西医结合]