传染性单核细胞增多症患儿CD3^＋CD4^-CD8^-T细胞与T淋巴细胞亚群变化情况及临床意义  

Study on the changes and clinical significance of the DNT cells and T lymphocyte subtype in children with infectious mononucleosis

作　　者：薛慧琴[1] 朱镭[1] 赵锐[1] 郭慧敏[1] 杜卫丽[1] 

机构地区：[1]山西省儿童医院儿科,太原030013

出　　处：《中国医师杂志》2010年第6期772-774,共3页Journal of Chinese Physician

摘　　要：目的 研究传染性单核细胞增多症（IM）患儿外周血CD3^＋CD4^-CD8^-T细胞（DNT细胞）及T淋巴细胞亚群变化及其临床意义.方法 采用免疫荧光流式细胞技术检测了48例IM患儿及40例正常儿童外周血DNT细胞与T淋巴细胞亚群CD3^＋T细胞、CD3^＋CD4^＋T细胞及CD3＋CD8＋T细胞水平.结果 IM患儿DNT细胞百分比（9.39±4.89）%高于正常对照组（4.26±1.68）%（P＜0.01）,CD3^＋CD4^＋T细胞百分比（21.45±9.87）%明显低于对照组（32.43±5.07）%（P＜0.01）;而CD3＋T细胞及CD3＋CD8＋T细胞百分比均明显高于对照组（P＜0.01）.结论 IM患儿DNT细胞升高及T淋巴细胞亚群比例改变,提示IM患儿存在免疫功能异常,为IM患儿临床免疫治疗提供理论依据.Objective To study on the changes of the DNT cells and T lymphocyte subtype in chil- dren with infectious mononucleosis （1M） and its clinical significance. Methods The flow cytometry （FCM） was used to detected the DNT cells and other T lymphocyte subtype in 48 cases of IM. Results The study showed that DNT cells（9.39 ±4. 89）% were greatly increased in comparison with normal controls （NC） （4.26 ±1.68）%（P 〈0.01）. CD4cells（21.45±9.87）% were decreased （ P 〈0.01） andCD8 cells increased in comparison with NC （ 32.43 ± 5.07 ） % （ P 〈 0. 01 ）. Conclusion DNT cells and T lymphocyte subtype can be used to evaluate the immune function of children with infectious mononucleosis （IM） and provide guidance for adoptive immunotherapy.

关 键 词：传染性单核细胞增多症/免疫学/代谢 T淋巴细胞/免疫学/代谢 T淋巴细胞亚群/免疫学/代谢 抗原 CD3/免疫学/代谢 抗原 CD43/免疫学/代谢 抗原 CD8/免疫学/代谢 

分 类 号：R725.1[医药卫生—儿科]