E-选择素基因多态性与新疆维吾尔族、汉族原发性高血压相关性研究  

Relationship Between E-selectin Gene Polymorphism and Essential Hypertension in Uygur and Han in Xinjiang

作　　者：王忠[1] 陈少泽[2] 汪道文[1] 王丽[2] 丁虎[1] 徐宇军[1] 张景玉[3] 段军仓[2] 张望强[2] 

机构地区：[1]华中科技大学同济医学院同济医院心内科,湖北武汉430030 [2]石河子大学医学院第一附属医院,新疆石河子832000 [3]石河子大学医学院预防医学系,新疆石河子832000

出　　处：《医学临床研究》2010年第6期982-984,共3页Journal of Clinical Research

基　　金：[基金项目]基金项目：新疆生产建设兵团科技攻关计划项目（项目编号：2008GG39）;石河子大学自然科学与技术创新项目（项目编号：ZRKX2009YB22）

摘　　要：【目的】探讨E一选择素基因rs5361A／C、rs5355C／T两个等位基因多态性与新疆维吾尔族、汉族原发性高血压之间的相关性。【方法】选择新疆维吾尔族、汉族原发性高血压患者309例和368例，同时选取维吾尔族、汉族正常对照组300例和349例，采用TaqMan探针法对E选择素基因的2个等位基因多态性rs5361A／C、rs5355c／T进行检测。【结果】新疆维吾尔族、汉族原发性高血压组与正常对照组中rs5361A／C基因多态性均存在显著差异（P〈0．01），而新疆维吾尔族、汉族原发性高血压组与正常对照组中rs5355C／T基因多态性均无显著差异（P〉0．05）。【结论]E一选择素基因rs5355C／T等位基因多态性与新疆维吾尔族、汉族原发性高血压均无显著相关性，E一选择素基因rs5361C／T等位基因多态性与新疆维吾尔族、汉族原发性高血压均显著相关，E一选择素基因rs5361等位基因CC型可能是新疆维吾尔族和汉族原发性高血压病的独立致病因素。[Objective] To investigate the association between rs5361A/C, rs5355C/T gene polymorphisms in E-selectin and essential hypertension in Uygur and Han in Xinjiang. [Methods] A total of 309 essential hypertensive patients in Uygur, 368 essential hypertensive patients in Han, 300 normotensive controls in Uygur and 349 normotensive controls in Han were enrolled in this study. TaqMan assay was used to detect the rs5361A/C and rs5355C/T gene polymorphisms of E-selectin. [Results] The rs5361A/C gene polymorphism had significant difference between essential hypertensive patients and normotensive controls in Uygur and Han in Xinjiang（ P 〈0.01）. The rs5355C/T gene polymorphism had no significant difference between essential hypertensive patients and normotensive controls in Uygur and Han in Xinjiang（ P 〉0.05）. [Conclusion] The essential hypertension in Uygur and Han in .Xinjiang is not associated with rs5355C/T gene polymorphism of E- selectin, but it is associated with rs5361A/C allele gene polymorphism of E-selectin gene. CC type of rs5361 allele gene polymorphism may be the independent etiological factor of essential hypertension in Uygur and Han in Xinjiang.

关 键 词：高血压/遗传学 E选择素 多态现象(遗传学) 新疆(维吾尔自治区) 

分 类 号：R544.1[医药卫生—心血管疾病]