糖脂清对实验性2型糖尿病大鼠糖脂代谢的影响  

Effect of tangzhiqing on glycolipid metabolism in rats with experimental type 2 diabetes

作　　者：李玉红[1] 张德芹[1] 王茜[1] 李俊青[1] 张潇[1] 曾森[1] 刘虹[1] 胡利民[1] 

机构地区：[1]天津中医药大学中医药研究院天津市中药药理重点实验室方剂学教育部重点实验室,300193

出　　处：《天津中医药大学学报》2010年第2期77-79,共3页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：科技部国际合作项目资助(2009DFA31070);国家科技重大专项"重大新药创制"项目资助(2009ZX09102-128)

摘　　要：[目的]观察糖脂清对实验性2型糖尿病大鼠糖代谢和脂代谢紊乱的影响。[方法]采用Wistar大鼠喂饲高脂饲料8周后,一次性腹腔注射2%链脲佐菌素30 mg/kg的方法复制2型糖尿病动物模型。按糖脂清用药剂量为3.2,1.6,0.8 g生药/kg体质量灌胃给药,以血脂康(0.25 g/kg体质量)及二甲双胍(0.25 g/kg体质量)作为阳性对照药,给药30 d后检测空腹血糖、血脂、胰岛素、糖化血红蛋白水平。[结果]糖脂清能显著降低实验性2型糖尿病大鼠的空腹血糖水平,降低血脂含量,降低胰岛素,糖化血红蛋白水平,升高胰岛素敏感性,与模型组比较有显著性差异(P<0.05,P<0.01)。[结论]糖脂清对实验性2型糖尿病大鼠模型有降低血糖,调节血脂,改善糖脂代谢紊乱的作用。[Objective] To observe the effects of Tangzhiqing（TZQ） on glycolipid metabolism in experimental type 2 diabetic rats.[Methods] Wistar rats were fed with high fat diet for 8weeks and then were injected intraperitoneally with streptozotocin（STZ,30 mg/kg） to induce experimental type 2 diabetes.The model rats were administrated with medicine at the dose of 6,3,1.5g of crude drug/kg for 30 days,using metformin hydrochloride tablets（0.25 g/kg）,Xuezhikang（0.25 g/kg）as the control.At the end,the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin were measured.[Results] Compared with the model group,TZQ could obviously decrease the levels of the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin（P0.05,P0.01）,and increase insulin-sensitivity index.[Conclusion] TZQ can effectively regulate glycolipid metabolism disorder.

关 键 词：2型糖尿病 糖脂清 糖代谢 脂代谢 

分 类 号：R285.5[医药卫生—中药学]