单核细胞和中性粒细胞CD11b高表达与2型糖尿病及其大血管病变相关  

High CD11b expression on monocyte and neutrophile granulocyte correlates with type 2 diabetes mellitus complicated with macroangiopathy

作　　者：黄延玲[1] 杨香玖[1] 马红[1] 黄群[1] 张岩[1] 陈小敏[1] 

机构地区：[1]厦门大学附属中山医院内分泌科,361004

出　　处：《中华内分泌代谢杂志》2010年第6期474-475,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用免疫荧光技术和流式细胞仪测定对照组及2型糖尿病患者组单核细胞和中性粒细胞CD11b的表达,发现合并大血管病变患者的单核细胞和中性粒细胞CD1b水平均明显高于不合并大血管病变的2型糖尿病患者[3.85±1.46对2.88±0.92,6.36（4.58-9.79）对4.23（3.70-4.83）,均P〈0.01],单核细胞CD11b、中性粒细胞CD11b高表达可能是2型糖尿病大血管病变发生的独立危险因素.The expression of CD11b on monocytes and neutrophils were measured by direct immunofluorescence techiques and flow cytometry in controls and type 2 diabetic patients.CD11b expression on monocyte and neutrophil in diabetic patients with macroangiopathy was higher than that in cases without macroangiopathy [3.85±1.46 vs 2.88±0.92,6.36 （4.58-9.79） vs 4.23 （3.70-4.83）,both P〈0.01].Monocyte CD11b and neutrophil CD11b might be independent risk factors of macroangiopathy in type 2 diabetes mellitus.

关 键 词：单核细胞 中性粒细胞 CD11B 糖尿病 2型 大血管病变 炎症 

分 类 号：R587.2[医药卫生—内分泌]