低出生体重大鼠发育期骨骼肌形态结构变化及胰岛素抵抗情况  

Changes of skeletal muscle structure and insulin resistance in low birth weight rat

作　　者：李雯[1] 谢宗德[1] 盖建芳[2] 胡劲涛[1] 陈平洋[1] 李素萍[3] 

机构地区：[1]中南大学湘雅二医院新生儿科,长沙410011 [2]山西省儿童医院,太原 [3]湖南省妇幼保健院,长沙

出　　处：《中华内分泌代谢杂志》2010年第6期501-503,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：湖南省科技厅资助项目（2007SK3042）

摘　　要：观察低出生体重大鼠不同发育时期骨骼肌形态结构的变化和胰岛素抵抗情况.采用孕期低蛋白饮食法建立低出生体重仔鼠模型.于出生后7 d、21 d、2月龄测定仔鼠空腹血糖、血清胰岛素值,并检测骨骼肌形态结构.自7 d至2月龄,低出生体重仔鼠骨骼肌纤维均有明显萎缩、排列稀疏紊乱;2月龄时超微结构明显异常.2月龄内低出生体重仔鼠血糖和血清胰岛素与对照组比较无差异.To study the changes in skeletal muscle structure and insulin resistance of low birth weight rats.The low birth weight filial rat model was established by feeding low protein diet to the pregnant rat during gestation.At 7 d,21 d,and 2 months,blood glucose and serum insulin were measured,and the structure of skeletal muscle was observed.From 7 d to 2 months,the muscle fibers of low birth weight rat were atrophic and arranged in disorder.The ultrastructure of skeletal muscle was also abnormal distinctly at 2 months.No differences of blood glucose and rerum insulin were found between the two groups.

关 键 词：低出生体重 大鼠 Sprague—Dawley 骨骼肌 胰岛素抵抗 

分 类 号：R714.5[医药卫生—妇产科学]