变应性鼻炎患者舌下含服粉尘螨滴剂免疫治疗早期鼻分泌物嗜酸细胞计数变化及临床意义  

Detection of EOS in the nasal section of the early stage in patients with allergic rhinitis treated with sublingual specific immunotherapy

作　　者：孟庆翔[1] 谢景华[1] 苏芳[1] 王磊[1] 

机构地区：[1]广州市第一人民医院耳鼻喉科,广州510000

出　　处：《山东大学耳鼻喉眼学报》2010年第3期36-39,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的探讨变应性鼻炎舌下含服粉尘螨滴剂免疫治疗早期鼻分泌物嗜酸细胞计数及与临床症状的关系。方法对43例行舌下含服粉尘螨滴剂免疫治疗的变应性鼻炎患者,在免疫治疗前及治疗后2、4、8周采集鼻腔分泌物,经涂片染色后计数鼻分泌物嗜酸细胞,并分析其与临床症状的可能相关性。结果舌下含服粉尘螨滴剂免疫治疗后4、8周鼻分泌物嗜酸细胞计数较免疫治疗前下降,差异有统计学意义(P<0.05);免疫治疗后4周及8周主观症状有明显改善的患者鼻分泌物嗜酸细胞计数较免疫治疗前下降,差异有统计学意义(P<0.05)。结论舌下含服粉尘螨滴剂治疗变应性鼻炎时,鼻黏膜局部免疫状态的改变在免疫治疗后4周或更早的时间已经发生。Objective To explore the relationship in the early stage between EOS in the nasal section and clinic syndromes in patients with allergic rhinitis treated with sublingual specific immunotherapy.Methods 43 patients with allergic rhinitis treated with sublingual specific immunotherapy were enrolled in this study.EOS account in the nasal sections was carried out before the treatment and 2,4 and 8 weeks after the treatment.Result After 4 and 8 weeks,expression of EOS in the nasal section in all cases and in cases with alleviation of clinic syndromes was statistically decreased（P0.05）.Conclusion The local immune status of nasal mucosa was changed after 4 week of sublingual immunotherapy in patients with allergic rhinitis.

关 键 词：鼻炎 变应性 嗜酸细胞 免疫治疗 螨 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]