自组装药物传递系统  

Self-assembled drug delivery system

作　　者：金义光[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所七室,北京100850

出　　处：《国际药学研究杂志》2010年第3期165-169,186,共6页Journal of International Pharmaceutical Research

基　　金：国家"重大新药创制"科技重大专项--综合性新药研究开发技术大平台资助项目(2009ZX09301-002)

摘　　要：自组装药物传递系统(SADDS)是基于药质体提出的新概念和新给药系统,融合了前药、分子自组装和纳米技术,是两亲前药形成的自组装纳米体系。其突出的特点是自组装体几乎没有辅料的参与,载药量大,稳定性好,在体内可获得靶向、控释效果,特别适合于抗病毒和抗肿瘤治疗。SADDS是学科交叉的产物,是药剂学研究的新方向。本文阐述了SADDS概念的来源、特点和研究进展,并展望了SADDS的研究前景。Self-assembled drug delivery system（SADDS） is a novel concept and a novel drug delivery system based on pharmacosomes. It integrates prodrug,molecular self-assembly and nanotechnology and can be defined as the nanosized self-assembled system formed from amphiphilic prodrugs. Its outstanding advantages include：a） the self-assemblies composed of prodrugs without excipients; b） high drug loads; c） strong stability; and d） in vivo targeting and controlled release. It can be applied to antiviral and anticancer therapy. SADDS is an inter-disciplinary product representing the latest progress in pharmaceutics. This paper describes the concept resource,characteristics and research progress in SADDS and analyzes the prospective of SADDS.

关 键 词：前药 自组装 纳米技术 自组装药物传递系统 药质体 靶向制剂 

分 类 号：R943.4[医药卫生—药剂学] R944.9[医药卫生—药学]