血清S-100蛋白对早期预测新生儿围生期脑损伤预后的价值  

The value of serum S-100 protein in early forecasting the prognosis of brain injury in perinatal stage

作　　者：王德胜[1] 李薇[1] 陈就好[1] 郑惊雷[2] 黄柏枝[1] 陈韦静[1] 赖丽芝[1] 

机构地区：[1]广东省东莞市太平人民医院新生儿科,广东东莞523900 [2]广东省东莞市人民医院外科,广东东莞523018

出　　处：《中国当代医药》2010年第18期11-12,15,共3页China Modern Medicine

摘　　要：目的:探讨血清S-100蛋白变化与新生儿围生期脑损伤预后的关系,为早期预测新生儿围生期脑损伤预后和早期干预及治疗提供依据。方法:选择40例围生期脑损伤新生儿为研究组,选择20例同期出生的正常新生儿为对照组。两组均于生后48～72h进行血样采集,采用ELISA法测定血S-100水平,以盖塞尔量表定期追踪两组发育情况。结果:研究组血S-100蛋白水平高于对照组[(1.55±0.79)μg/Lvs(0.62±0.46)μg/L,t=4.89,P<0.01],盖塞尔量表评价两组发育情况,两组间平均发育商比较显示3月龄始研究组低于对照组,差异有统计学意义。结论:测定血S-100蛋白变化对早期预测围生期脑损伤儿预后有较高的价值。Objective： To explore the correlationship of the change of blood serum S-100 protein with the prognosis of perinatal brain damage, so as to provides the theory data for the promptly forecasting and early intervention for the brain damage of perinatal stage. Methods： 40 cases of newborns with perinatal brain damage were selected as the study group, and 20 cases of normal newborns in same period were selected as the control group. In the 48-72 hours after birth, blood samples were sampled in both groups. The Serum S-100 protein level of both groups were detected by ELISA. The physical, neurological conditions and intelligence test of the both groups were studied by Gesell Development Scale regularly . Results： The serum S-100 protein level were higher in the study group than the control group[（1.55±0.79） μg/L vs （0.62±0.46） μg/L,t=4.89, P0.01]. The average marks of development quotient were lowered in the study group than the control group after 3 months old of the children, and the difference between the two groups were significant. Conclusion： The serum S-100 protein could be used as a promising index in early forecasting of the prognosis of brain injury in perinatal stage.

关 键 词：新生儿 围生期脑损伤 S-100蛋白 预后 早期预测 

分 类 号：R714.7[医药卫生—妇产科学]