大鼠吗啡条件性位置偏爱期间前额叶皮质和伏隔核中GluR1、GluR2阳性神经元的变化  

CHANGES OF GLUR1 AND GLUR2 POSITIVE NEURONS IN PREFRONTAL CORTEX AND NUCLEUS ACCUMBENS OF RATS WITH MORPHINE INDUCED CONDITIONED PLACE PREFERENCE

作　　者：赵雪松[1] 李峰[1] 宋月晗[1] 刘洋[1] 焦莹[1] 刘晓兰[1] 刘燕[1] 丁洋[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国药物依赖性杂志》2010年第3期175-179,共5页Chinese Journal of Drug Dependence

基　　金：教育部博士点基金资助

摘　　要：目的:研究吗啡依赖期间大鼠前额叶皮质和伏隔核中GluR1、GluR2阳性神经元的变化。方法:采用免疫组织化学实验方法观察吗啡条件性位置偏爱模型大鼠前额叶皮质和伏隔核中GluR1和GluR2阳性神经元的形态及数目变化。结果:与空白对照组比较,吗啡模型组GluR1和GluR2的阳性神经元数均明显升高(P<0.01)。结论:大鼠条件性位置偏爱期间前额叶皮质和伏隔核中GluR1和GluR2的阳性神经元增多,提示AMPA受体GluR1和GluR2两个亚基参与了吗啡精神依赖的形成。Objective：To study the changes of GluR1 and GluR2 positive neurons in the prefrontal cortex and nucleus accumbens of rats with morphine-induced conditioned place preference（CPP）.Methods：This paper used immunohistochemistry method to observe the morphology and numbers of GluR1 and GluR2 positive neurons in the rats with morphine-induced CPP.Results：GluR1 and GluR2 positive neurons increased significantly（P0.01）in the rats with morphine-induced CPP,compared with those in normal control group.Conclusion：The increased GluR1 and GluR2 positive neurons in prefrontal cortex and nucleus accumbens of morphine induced CPP rats participate in the formation of morphine psychological dependence.

关 键 词：吗啡 前额叶皮质 伏隔核 GLUR1 GLUR2 条件性位置偏爱 

分 类 号：R595.5[医药卫生—内科学]