LIFR在原发不孕症患者子宫内膜的表达  

Expresstion of leukaemia inhibitory factor's receptor in endometrial of the patients with unexplained infertility

作　　者：张松灵[1] 李春红[1] 魏振彤[1] 田海涵 

机构地区：[1]吉林大学第一医院妇产科,吉林长春130021 [2]通辽市红星医院妇产科,内蒙古通辽028007

出　　处：《中国实验诊断学》2010年第6期881-883,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技厅科技发展计划白求恩基金资助项目(合同编号200705155)

摘　　要：目的探讨白血病抑制因子受体(Leukaemia inhibitory factor receptor,LIFR)在子宫内膜的表达,与原因不明原发不孕症的关系。方法采用逆转录聚合酶链反应(RT-PCR)技术,检测30例研究组(原因不明原发不孕症患者)和20例对照组患者分泌中期子宫内膜LIFRmRNA的表达。结果研究组分泌中期子宫内膜LIFRmRNA表达水平为0.640 1±0.234 9,对照组为1.558 7±0.296 1,研究组较对照组明显降低,差异有极显著性(P<0.001)。结论 LIFR表达减少或缺失,可能与原因不明原发不孕症有关。Objective To investigate the expression of endometrial leukaemia inhibitory factor＇ s receptor （LIFR） in patients with unexplained infertility.Methods By a quantitative reverse transcription-polymerase chain reaction （RT-PCR）, we detected the expression of LIFR in endometrium during mid-luteal phase in 30 cases infertility group （unexplained infertility）and 20 cases control ~;roup. Results The level of LIFRmRNA expression on endometrium during mid-luteal phase in infertility group was, significantly lower than those in the control group. Conclusion The decreased expression of LIFR might be one of the major causes of unexplained infertility.

关 键 词：子宫内膜 白血病抑制因子受体 卵植入 不孕症 

分 类 号：R711.6[医药卫生—妇产科学]