中国东北汉族人群解偶联蛋白3基因-55C/T多态性与2型糖尿病相关性研究  

uncoupling protein 3 gene-55C→T variant with Type 2 Diabetes Mellitus in Han population northeast in Chinese

作　　者：刘佳南[1] 王茜[2] 吴玫[1] 郑锦花[1] 张桂珍[1] 

机构地区：[1]吉林大学中日联谊医院中心研究室,吉林长春130033 [2]吉林大学中日联谊医院肾内科,吉林长春130033

出　　处：《中国实验诊断学》2010年第6期896-898,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨解偶联蛋白3(uncoupling protein 3,UCP3)基因-55C→T变异与中国东北地区2型糖尿病的关系。方法用聚合酶链反应-限制性片段长度多态性检测100例2型糖尿病患者(男/女为58/42)及113名糖耐量正常者(男/女为56/57)UCP3基因-55C→T变异的基因型。结果 2型糖尿病组与正常对照组三种基因型频率及等位基因频率分布差异均有显著性意义,P值分别为0.027和0.003,两组间携带T的基因型(CT+TT)频率差异有显著意义(P=0.008);T等位基因与2型糖尿病患者血清总胆固醇(CHOL)及低密度脂蛋白(LDLC)频率升高相关(P为0.021,0.024)。结论 UCP3基因-55C→T变异与中国东北汉族人群2型糖尿病患者局部体脂代谢存在相关性,该基因变异与2型糖尿病发病相关。Objective To investigate the relationship of UCP3 gene -55C→T variant with Type 2 Diabetes MeUitus in Han population northeast in Chinese. Methods Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）was used to detect the genotype of UCP3 gene -55C→T in a total of 213 Chinese including 113 individuals with normal glucose tolerance（NGT） and 100 patients with type 2 diabetes.Results Type 2 diabetes groups have the significance with the normal control group of geno- type frequencies and the allele frequency distribution difference（P = 0.027and P = 0.003） ,during two groups carry T the genotype （ CT ＋ TT） frequency difference to have the remarkable significance （P = 0. 008） ; The T allele and Type 2 diabetes groups of choles- terol （CHOL） and the low density hpoprotein （LDL） on frequency ascension correlation （P = 0. 021,0. 024）Conclusion Although UCP3 gene -55C→T variant is associated with type 2 diabetes Mellitus northeast in Chinese.

关 键 词：解偶联蛋白3基因 2型糖尿病 多态性 

分 类 号：R587.1[医药卫生—内分泌]