妊娠糖尿病患者血清CRP、IL-6水平的变化及其临床意义  

Changes in serum and Clinical significance of CRP and IL-6 Levels in Patients with Gestatinal Diabetes Mellitus

作　　者：刘波[1] 林海[1,2] 石琳琳[1] 蒋鸿阳[1] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130033 [2]空军航空大学校务部门诊部,吉林长春130022

出　　处：《中国实验诊断学》2010年第6期899-901,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨炎症因素在妊娠期糖尿病发生、发展中的意义。方法选取116名孕12-16周的孕妇作为研究对象,按照ADA诊断标准将研究对象分为妊娠糖尿病组(GDM)、妊娠糖耐量异常组(IGT)及妊娠葡萄糖耐量正常组(NGT)。分别检测各组患者空腹血糖,空腹胰岛素,血清CRP,血清IL-6的水平,计算胰岛素抵抗指数(HOMA-IR),并进行统计学分析。结果与NGTI、GT组比较,GDM组血清CRPI、L-6、HOMA-IR值明显升高,差异有统计学意义(P<0.05)。妊娠晚期与妊娠早期比较CRPI、L-6、HOMA-IR值明显升高,差异有统计学意义(P<0.05)。结论血清CRP、IL-6等炎症因子与妊娠糖尿病患者胰岛素抵抗密切相关,参与了妊娠期糖尿病的发生、发展。Objective To investigate the significance of inflammatory factors in pat hogenesis of gestational diabetes mellitns. Methods To select 116 women of pregnancy 12-16 weeks as study objection. With the ADA diagnosis stand ard, to divide study ob- jection into different glucose tolerance group s： GDM,IGT and NGT respectively. To test the serum of FBS,FINS,CRP and IL-6 levelof GDM. IGT, NGT group respectively, and to. Calculate the HOMA IR. Results The serum CRP, IL-6 level and insulin resistance were significantly higher in GDM group than in NGT and IGTgroup. The serum CRP, IL-6 level and insulin resistance were significantly higher in late genarationg of GDM than early genarationg of GDM. （ P 〈 0.05）. Conclusion inflammatory factors such as CRP, IL- 6 closely related to insulin resistance and participate in the process of occurence and development of GDM.

关 键 词：妊娠糖尿病 CRP IL-6 胰岛素抵抗指数(HOMA-IR) 

分 类 号：R714.25[医药卫生—妇产科学]