NKT细胞发育及功能研究进展  

Progresses in development and function of NKT cells

作　　者：谭锦泉[1] 肖威[1] 王岚[1] 何玉玲[1] 

机构地区：[1]武汉大学基础医学院免疫系,武汉430071

出　　处：《中国免疫学杂志》2010年第6期483-487,493,共6页Chinese Journal of Immunology

摘　　要：自然杀伤T细胞(Natural killer T cells,NKT细胞)是一类天然存在的介导先天性免疫和获得性免疫的重要淋巴细胞,参与机体的抗感染、抗肿瘤、移植免疫和自身免疫调节作用。NKT细胞的来源、选择分化和成熟过程及其调控研究有了很大的进展,同时在这些过程中仍存在一些备受争议和值得深入研究的问题。清楚了解NKT细胞的分化发育过程和调控机制,结合NKT细胞的生物学功能特征,将对临床预防和治疗相关的免疫性疾病具有重要的指导意义。Natural killer T （NKT） cells,a subset of lymphocytes that bridge innate and adaptive immune systems,involve in processes of infection immunity,tumor immunity,transplantation immunity and autoimmunity.A significant progress has been made in the mechanisms of origin,selection,differentiation and maturation of NKT cells.However,some viewpoints are still controversial,and need to be further intensively investigated.The potential therapeutic applications of functional NKT cells have been suggested in the prevention and the treatment of various diseases.

关 键 词：NKT细胞 CD1d限制性 胸腺 选择分化 

分 类 号：R392[医药卫生—免疫学]