HLA-G蛋白在子宫腺肌病中的表达及其作用机制  被引量:1

Expression of HLA-G protein in adenomyosis and its functions

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作  者:赵倩[1] 任云青[2] 薛丽萍 李培莉[2] 王亚香 

机构地区:[1]山西医科大学,太原030001 [2]山西医科大学汾阳学院,汾阳032200 [3]山西省汾阳医院妇产科,汾阳032200

出  处:《中国免疫学杂志》2010年第6期510-513,共4页Chinese Journal of Immunology

摘  要:目的:探讨HLA-G蛋白在子宫腺肌病中的作用机制。方法:采用免疫组织化学染色方法与Western blot方法检测31例子宫腺肌病患者在位与异位内膜组织HLA-G蛋白表达,18例子宫肌瘤患者正常子宫内膜作为对照。结果:子宫腺肌病患者在位与异位内膜组织腺上皮、间质细胞均有HLA-G蛋白表达,而子宫肌瘤患者(对照组)正常内膜中未检测到HLA-G蛋白;子宫腺肌病患者在位与异位内膜组织HLA-G蛋白表达无显著性差异(P>0.05);子宫腺肌病患者在位内膜分泌期和增生期HLA-G蛋白表达无显著性差异(P>0.05)。结论:子宫腺肌病患者在位与异位内膜组织HLA-G蛋白异常表达,可能与其发病有关。Objective:To investigate the role of HLA-G protein in the pathogenesis of adenomyosis.Methods:Immunohistochemistry and Western blot methods were used for detecting the expression of HLA-G protein in eutopic endometrium and ectopic endometrial tissues of 31 patients with adenomyosis (AM),normal endometrial tissues of 18 patients only with hysteromyoma were recruited as control group.Results:The expression of HLA-G was in glandular and stromal cells in eutopic and ectopic endometrium of patients with AM,whereas the expression of HLA-G in normal endometrium of patients with hysteromyoma(control group) was not detected;There was no obvious difference in the expression of HLA-G protein between eutopic and ectopic endometrium of the patients with AM(P0.05);There was no significant difference in the expression of HLA-G in eutopic endometrium of the patients with AM between proliferative phase and secretory phase(P0.05).Conclusion:The abnormal expression of HLA-G protein in eutopic and ectopic endometrium tissues may play a key role in the pathogenesis of adenomyosis.

关 键 词:人类白细胞抗原-G 子宫腺肌病 免疫耐受 

分 类 号:R711.71[医药卫生—妇产科学]

 

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