基于中医药特点的中药体内外药效物质组生物/化学集成表征新方法  

Biological-chemical profiling of in vitro and in vivo bioactive compounds from traditional Chinese medicines with holistic views

作　　者：齐炼文[1] 周建良[1] 郝海平[2] 李会军[1] 闻晓东[1] 陈君[1] 杨中林[1] 李萍[1] 王广基[2] 

机构地区：[1]中国药科大学现代中药教育部重点实验室,南京210009 [2]中国药科大学药物代谢动力学重点实验室,南京210009

出　　处：《中国药科大学学报》2010年第3期195-202,共8页Journal of China Pharmaceutical University

基　　金：国家杰出青年科学基金资助项目(No.30325046);国家自然科学基金重大研究计划资助项目(No.90209045),国家自然科学基金资助项目(No.30472160),国家自然科学基金重点资助项目(No.30530870,No.30630076)~~

摘　　要：中药药效物质基础研究一直是中医药现代化的关键问题之一。近几十年来,中药药效物质研究虽已取得了长足的进步,但还存在明显不足,符合中药特点的药效物质研究关键技术体系尚不完善。作者及其研究团队针对中药药效物质基础的国内外研究现状,集成多学科的理论和技术,在学术思想、研究思路和研究方法等方面进行了探索,通过近十年的系统研究,建立了基于整体观、符合中医药特点和具有普适性的中药复杂药效物质研究关键技术与方法学体系,包括中药多组分表征技术、中药生物体内动态药效物质研究技术、生物捕集-化学集成表征新技术、中药多成分整合作用研究技术、适宜于中药特点的多指标质量控制技术。研究成果为中药药效物质基础及作用机制研究提供了技术支撑。Elucidating the bioactive constituents in Chinese herbal medicines（CHMs）has become one of the key issues for the modernization of CHMs.During the last decades,great advancements have been made on the elucidation of bioactive compounds from CHMs.However,most researchers and pharmaceutical industries tend to approach CHMs in a characteristically western way that is to isolate active ingredients and test them one by one.Therefore,it is necessary to develop methodologies consistent with their own characteristics that the whole CHMs are a set of multi-component parts self-organized into an interactive and indivisible whole.Combining multidisciplinary technologies,Prof.Ping Li＇s research team has obtained significant innovation in academic theories,research ideas and methodologies.After about ten years of investigation,they have successfully developed a technical platform that is consistent with holistic views and characteristics of CHMs for studying bioactive compounds.This technical platform includes multi-component profiling technique,in vivo dynamic evaluation technique,biological fishing-chemical analyzing technique,multi-component interactive studying technique and multi-index quality control technique.The project provides insights and technical supports for the innovation of discovering bioactive constituents and studying integrative mechanism.

关 键 词：中药药效物质 生物捕集-化学集成表征 多组分表征 质量控制 整合作用 体内动态药效物质 

分 类 号：R284.1[医药卫生—中药学]