中药前胡物质基础的系统研究  

Systematic research of the material base of Radix Peucedani(Qianhu)

作　　者：孔令义[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210009

出　　处：《中国药科大学学报》2010年第3期203-207,共5页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.29872058);江苏省青年科技基金资助项目(No.BQ96019);高等学校优秀青年教师教学科研奖励计划资助项目(No.200120)~~

摘　　要：针对中药前胡在中医药学中的重要地位和研究现状,对中药前胡的生物活性成分开展了深入系统的研究。以前胡中的化学成分为主线,以药理学指标为指导,对其有效成分和生物活性成分进行了提取分离、结构鉴定、对映体拆分、结构修饰和全合成等系统深入的研究。在此基础上对前胡代用品使用的合理性、前胡质量标准的制订、前胡中特征性成分的分离方法、结构测定方法等内容开展了系统研究。本文旨在阐明前胡临床疗效的物质基础,并在此基础上制订前胡的质量标准,为研究和开发具有我国特色、并具有自主知识产权的新药奠定基础。Radix Peucedani（Qianhu）,the root of Peucedanum praeruptorum Dunn or Peucedanum decursivum（Miq.）Maximo（Umbelliferae）,possesses the efficacy of dispelling wind-heat,relieving cough and reducing sputum.It has been used for the treatment of colds and headaches,cough,dyspneal fullness and tightness in the chest,etc.Both the Traditional Chinese Medicine（TCM）theory and the clinical practice have proved that Radix Peucedani is an important Chinese medicines for curing respiratory diseases.In the light of the importance and research status of Qianhu,this project focused on the chemical constituents of Qianhu,guided by the pharmacological efficacy of its clinical relevance.A series of systematic studies have been carried out,which including the extraction and separation,structural elucidation,enantiomer separation,structural modification and total synthesis of bioactive constituents of Qianhu.Based on these systematic studies,further studies were foucus on the rationality evaluation of the use of its substitutes,scientifically design of its quality control standards,the separation and structural elucidation of its characteristic constituents,etc.The main goal is to clarify the material basis of the clinical efficacy of Qianhu and propose a scientific quality control standard for the development of the new drugs with Chinese characteristics and independent intellectual property rights.

关 键 词：前胡 物质基础 系统研究 

分 类 号：R284[医药卫生—中药学]