无症状心肌缺血虚实证血浆ANP及TXA_2/PGI_2的临床研究  

Clinical Research on Plasma ANP and TXA 2/PGI 2 of Symptomless Myocardial Ischemia Patients

作　　者：李松[1,2] 马伟东[1,2] 陈镜合[1,2] 

机构地区：[1]广州中医药大学第一附属医院急症中心 [2]广东省惠州市中心医院心血管内科

出　　处：《南京中医药大学学报》1999年第2期79-80,共2页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：广东省中医药管理局资助

摘　　要：目的：探讨无症状心肌缺血血浆心钠素以及血管紧张素和前列环素水平的改变及其与中医证型的关系。方法：５７例无症状心肌缺血患者分虚（２０例）、实（３７例）证型及正常对照组（２２例），分别检测血浆ＡＮＰ、ＴＸＡ２和ＰＧＩ２水平。结果：无症状心肌缺血虚证组血浆ＡＮＰ（１８５．５４±１３．３４ｐｇ／ｍｌ）明显高于对照组（１０１．５２±３２．７７ｐｇ／ｍｌ）（Ｐ＜０．０１），而实证组（７９．４５±２０．２０ｐｇ／ｍｌ）则低于对照组（Ｐ＜０．０５）。实证组、虚证组与对照组比较，ＴＸＡ２、ＴＸＡ２／ＰＧＩ２升高（Ｐ＜０．０１），但血浆ＰＧＩ２差异不显著。无症状心肌缺血患者虚证组血浆ＡＮＰ明显高于实证组（Ｐ＜０．０１），在ＴＸＡ２、ＴＸＡ２／ＰＧＩ２变化上，虽实证组高于虚证组，但无显著性意义。结论：无症状心肌缺血出现明显血管紧张素／前列环素系统的紊乱，以及心钠素代偿性变化，心钠素的代偿性变化与中医证型有关，实证降低，虚证则代偿性升高。而ＴＸＡ２、ＴＸＡ２／ＰＧＩ２的变化与中医虚实证型无关。OBJECTIVE:To investigate into the relationship between changes in ANP,TXA 2 and PGI 2 and TCM syndrome types in symptomless myocardial ischemia patients.METHOD:57 patients were divided into 20 with syndrome of deficiency type and 37 with syndrome of excess type,compared with a control group of 22 persons,and the levels of ANP,TZA 2 and PGI 2 were detected.RESULT:In patients with syndromes of deficency type,the plasma ANP (185.54±13.34 pg/ml) was significantly higher than that in the control group(101.53±32.77 pg/ml)(P<0.01),whereas in patients with syndromes of excess type,plasma ANP(79.45±20.20 pg/ml) was lower than in the control group(P<0.05).TXA 2 and TXA 2/PGI 2 rose(P<0.01) as compared with the control group,but no marked difference in plasma PGI 2 was detected.Plasma ANP of patients with deficency syndromes was markedly higher than those with excess syndromes (P<0.01).The TXA 2,TXA 2/PGI 2 in the latter is higher than in the former with no marked significance.CONCLUSION:The marked disorder in TXA 2/PGI 2 in symptomless myocardial ischemia patients and the compensatory changes in ANP are related to the TCM sydromes of the disease.Changes in TXA 2 and TXA 2/PGI 2 are not related to the TCM syndromes..

关 键 词：无症状心肌缺血 心钠素 前列环素 辨证分型 

分 类 号：R259.422[医药卫生—中西医结合]