卡介苗多糖核酸辅助治疗白癜风的疗效及对T淋巴细胞亚群的影响  

BCG PSN adjuvant treatment of vitiligo and on t-lymphocyte subpopulation

作　　者：殷现鹏[1,2] 韩冰[2] 郭钰琪[1] 

机构地区：[1]山东省医学科学院,山东济南250062 [2]山东省邹城市人民医院,山东邹城273500

出　　处：《济宁医学院学报》2010年第3期167-169,共3页Journal of Jining Medical University

摘　　要：目的观察卡介苗多糖核酸辅助治疗白癜风的疗效及对外周血T淋巴细胞亚群的影响。方法90例白癜风患者随机分为实验组(50例)和常规治疗对照组(40例),比较卡介苗多糖核酸辅助治疗后T淋巴细胞亚群比例变化。结果治疗后实验组总有效率明显高于常规治疗对照组(54%VS 27.5%,P<0.05);治疗前白癜风患者外周血CD3、CD4及CD4/CD8较正常低(P<0.05),治疗后实验组CD3、CD4及CD4/CD8均升高,与治疗前比较有显著性意义(P<0.05),而常规治疗组治疗前后比较无显著性差异(P>0.05)。结论白癜风患者存在T细胞免疫功能异常,采用卡介苗多糖核酸辅助治疗能提高患者的CD4+T细胞亚群比例,临床可获得较好疗效。Objective To observe BCG PSN assisted Vitiligo and peripheral T lymphocyte subsets.Methods Of 90 cases of Vitiligo were randomly divided into experimental groups（50 cases）,and the General treatment of the control group（40 patients）,and compared the BCG vaccine adjuvant therapy after PSN T lymphocyte subsets.Results Experimental group total effective 54%,General treatment control group is 27.5%（P0.05）.Before the treatment,patients with Vitiligo CD3,CD4 and CD4/CD8 below normal（P0.05）.After treatment,the CD4 comprehensive set of CD3,and CD4/CD8 were significantly elevated,and there were no significant changes for the control group（P0.05）.Conclusion Vitiligo have t-cell immune dysfunction.Using BCG PSN adjuvant therapy can improve the patient＇s CD4＋T cell subsets with better clinical outcomes.

关 键 词：卡介苗多糖核酸 白癜风 T淋巴细胞亚群 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]