腰臀比与初发2型糖尿病患者胰岛β细胞早期分泌的关系  

Impact of waist/height ratio on insulin resistance and function of pancreatic β-cells in newly diagnosed Type 2 diabetes mellitus

作　　者：刘海霞[1] 李红艳[1] 卢洪文[1] 张奕[1] 逄力男[1] 

机构地区：[1]山东省潍坊市人民医院内分泌科,261041

出　　处：《中国医药》2010年第7期604-606,共3页China Medicine

摘　　要：目的 研究腹型肥胖对初发2型糖尿病胰岛β细胞早期分泌相的影响.方法 将86例初诊2型糖尿病患者按照腰臀比0.85（男）或0.80（女）分为腹型肥胖组（52例）和非腹型肥胖组（34例）.观察这些患者的血糖、血脂等代谢指标以及胰岛素抵抗指数（HOMA-IR）、早期胰岛素分泌指数（HOMA-IS）、快速相胰岛素分泌指数（ISF-Arg）等胰岛素分泌指标.结果 非腹型肥胖组糖化血红蛋白（9.1±2.7）%,高于腹型肥胖组的（8.5±2.4）%,2组SBP、TG、HDL-C相比,差异有统计学意义（P＜0.01）[非腹型肥胖组分别为（126.2±18.1）mm Hg（1 mm Hg=0.133 kPa）、（1.49±0.78）mmol/L、（1.3±0.3）mmol/L,腹型肥胖组分别为（134.2±17.4）mm Hg、（2.24±1.01）mmol/L、（1.1±0.4）mmol/L].经校正,非腹型肥胖组患者的ISF-Arg、HOMA-IS明显低于腹型肥胖组[（2.88±0.12）vs（3.75±0.10） （2.86±0.13）vs（3.65±0.01） P＜0.01].结论 以腰臀比作为腹型肥胖指标有助于初步判断患者胰岛β细胞早期分泌.Objective To study the impact of central obesity on insulin resistance and the function of pancreaticβcells in newly diagnosed Type 2 diabetes. Methods Eighty-six type 2 diabetes mellitus （T2DM） patients were divided into 2 groups according to their waist to hip ratio. Metabolic parameters and Insulin resistance and the function of pancreatic β-cells were compared. Insulin resistance were calculated by HOMA-IR and the function of pancreatic β-cells were detected by HOMA-βand ISF-Arg. Results HOMA-IR index, HOMA-IS and ISF-Arg in WHR ≥0.85 （male） or 0.80 （female） group were significantly higher than that of WHR 〈 0. 85 （male） or 0. 80 （female） group （ P 〈 0. 01 ）, whereas WHR 〈 0. 85 （male） or 0. 8 （ female ） group had significantly higher fasting sugar levels and HbA1c and favorable lipid profile （P 〈 0.05 ）. Conclusion WHR is an useful parameter in roughly judging the function of β-cell and insulin resistance.

关 键 词：体质指数 腰臀比 糖尿病 2型 胰岛素抵抗 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]