反相高效液相色谱法考察注射用炎琥宁与注射用更昔洛韦配伍稳定性  

Stability of potassium sodium dehydroandrographolide succinate for injection and ganciciovir for injection by HPLC-DAD

作　　者：陆连英[1] 郑芳[1] 李志浩[1] 

机构地区：[1]郧阳医学院附属东风医院药剂部,湖北省十堰市442008

出　　处：《中国医药》2010年第7期629-631,共3页China Medicine

摘　　要：目的 考察注射用炎琥宁与注射液用更昔洛韦在5%葡萄糖注射液中的配伍稳定性.方法 在室温[（20±1）℃]下,采用反相高效液相色谱法-二极管阵列检测器同时测定炎琥宁与更昔洛韦配伍后0～8 h内的含量变化,并观察配伍液的外观及pH值.结果 检测波长为251 mm,炎琥宁的平均回收率为99.8%,峰面积相对标准偏差（RSD）为0.84%（n=9）,更昔洛韦的平均回收率为99.7%,RSD为0.68%（n=9）.8 h内配伍液的颜色、pH值以及炎琥宁与更昔洛韦的含量均变化较大.结论 在室温条件下,注射用炎琥宁与注射液用更昔洛韦不可以在5%葡萄糖注射液中配伍使用.Objective To study the stability of potassium sodium dehydroandrographolide succinate for injection and ganciclovir for injection in 5% glucose injection. Methods At ambient temperature [ （20 ± 1）℃ ], the changes of the contents of potassium sodium dehydroandrographolide succinate and ganciclovir were determined simultaneously by HPLC-DAD, and the changes of apperance, pH value were observed within 8 hours. Results Significant changes were observed in the content, apperance and pH value for the mixed solution within 8 hours.Conclusion Potassium sodium dehydroandrographolide succinate for injection cannot be mixed with ganciclovir for injection in glucose injection at ambient temperature.

关 键 词：色谱法 高效液相 炎琥宁 更昔洛韦 配伍禁忌 稳定性 

分 类 号：R917[医药卫生—药物分析学]