退变腰椎间盘髓核组织中ADAMTS-5蛋白表达的临床意义  

Clinical significance of ADAMTS-5 expression in the nucleus pulposus of degenerated lumbar discs

作　　者：卢永江[1] 徐杰[1] 

机构地区：[1]福建医科大学省立临床医学院福建省立医院骨二科

出　　处：《福建医药杂志》2010年第3期92-94,共3页Fujian Medical Journal

摘　　要：目的探讨ADAMTS-5蛋白在退变的腰椎间盘髓核组织中的表达的意义。方法采用免疫组织化学方法检测30例退变突出腰椎间盘患者(退变组)和28例腰椎骨折患者(对照组)腰椎间盘髓核组织ADAMTS-5蛋白表达情况。结果退变组27例(90.0%)表达阳性,对照组3例(10.7%)表达阳性,差异有统计学意义(χ2=17.8,P<0.05)。结论 ADAMTS-5蛋白高表达可能是腰椎间盘退变突出的重要因素之一。Objective To study the clinical significance of a disintegrin and metalloproteinase with thrombospondin motif-5（ADAMTS-5）expression in pulpy nucleus of human degenerated intervertebral intervertebral disc.Methods The expression of ADAMTS-5 enzyme in fresh nucleus pulposus of 30 patients with intervertebral disc herniation（experimental group）and 28 patients with intervertebral fracture（control group）were used for immunohistochemical analyses.Results The expression of ADAMTS5 enzyme was positively expressed in 27 cases（90.0%）in experiment group,but in the control group three cases（10.7%）showed positively reaction.The number of immunopositive cells in the nucleus pulposus staining for ADAMTS-5 in two groups show significant statistical difference （χ2=17.8,P0.05）.Conclusion The increased expression of ADAMTS-5 in degenerated nucleus pulposus indicates that the ADAMTS-5（aggrecanase-2） may be one of the important factors leading to intervertebral disc degeneration.

关 键 词：腰椎 椎间盘 ADAMTS-5 髓核组织 免疫组织化学 

分 类 号：R681.53[医药卫生—骨科学]