丙泊酚或异氟醚麻醉对单肺通气时氧化应激反应的影响  

Effects of propofol or isoflurane anesthesia on oxidative stress responses during one-lung ventilation

作　　者：赵晓玲[1] 曾小莉[1] 谢冲[1] 杨永慧[1] 高昌俊[1] 蒯建科[1] 于代华[1] 柴伟[1] 姚立农[1] 

机构地区：[1]第四军医大学唐都医院麻醉科

出　　处：《临床麻醉学杂志》2010年第5期376-378,共3页Journal of Clinical Anesthesiology

摘　　要：目的 观察丙泊酚或异氟醚麻醉对单肺通气（OLV）时氧化应激反应的影响.方法 48例择期行食管癌根治术患者,随机分为丙泊酚单肺通气组（Pro-OLV组）、异氟醚单肺通气组（Iso-OLV组）、丙泊酚双肺通气组（Pro-TLV组）和异氟醚双肺通气组（Iso-TLV组）,每组12例.于开胸前（T0）、OLV后（TLV组于开胸后）30 min（T1）、90 min（T2）、150 min（T3）、手术结束时（T4）测定血清超氧化物歧化酶（SOD）、丙二醛（MDA）及NO浓度.结果 与T0时比较,OLV组T1～T4时的SOD活性降低,MDA浓度及NO浓度升高（P〈0.01）,而TLV组无明显变化.与TLV组比较,OLV组T1～T4时的SOD活性降低,MDA及NO浓度升高（P〈0.01）.结论 丙泊酚或异氟醚麻醉均不能减轻OLV时氧化应激反应.Objective To observe the effects of propofol or isoflurane anesthesia on oxidative stress responses during onequng ventilation （OLV）. Methods Forty-eight patients scheduled for radical operation of esophagus cancer were randomized into 4 groups of propofol and OLV（group Pro OLV）, isoflurane and OLV（group Iso-OLV）, propofol and two-lung ventilation（group Prc TLV）, and isoflurane and TLV（group Iso-TLV） with 12 cases each. Serum levels of superoxide dismutase （SOD）, malondialdehyde （MDA） and nitric oxide （NO） were measured before opening the thoracic cavity（T0 ）, at 30 min （T1）, 90 min（T2 ）, and 150 min（Ta ） after OLV（after opening the thoracic cavity in TLV groups）, and at the end of operation （T4）. Results Compared with TO, SOD activity decreased and MDA and NO concentrations increased in OLV groups at T1-T4 （P〈0. 01）. However, there was no significant difference between two TI.V groups. Compared with TLV groups, SOD decreased and MDA and NO increased （P〈0. 01） in OLV groups at T1-T4. Conclusion Neither propofol nor isoflurane for the maintenance of anesthesia could mitigate the degree of oxidative stress responses during OLV.

关 键 词：丙泊酚 异氟醚 单肺通气 氧化应激 

分 类 号：R614[医药卫生—麻醉学]