益肾生血片治疗再生障碍性贫血的实验研究  

Experimental Study on Effect of Yishen Shengxue Tablet in Treating Aplastic Anemia

作　　者：周霭祥[1] 王天恩[1] 杨经敏 麻柔[1] 杨留[1] 邓成珊[1] 王奎[1] 庄杰盾 公殿广 刘锋[1] 许勇刚[1] 

机构地区：[1]中国中医研究院西苑医院血液病研究室

出　　处：《中国中西医结合杂志》1999年第3期170-173,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的：探讨益肾生血片治疗再生障碍性贫血（再障）的作用机理。方法：观察了该药对小鼠造血功能、免疫功能、抗感染力和抵抗力的影响。结果：益肾生血片对马利兰引起的造血损伤小鼠多能造血干细胞（ＣＦＵＳ）、粒系祖细胞（ＣＦＵＣ）和红系祖细胞（ＣＦＵＥ）的数量的恢复有明显促进作用；对正常小鼠腹腔巨噬细胞吞噬功能有明显促进作用；可明显降低接种金黄色葡萄球菌小鼠的死亡率；在常压缺氧时，可使小鼠耐缺氧能力明显提高，存活时间延长。结论：益肾生血片治疗再障有效可能是通过促进骨髓造血干细胞增殖，提高机体非特异性免疫力、抗感染力和抵抗力几方面作用来实现的。Objective: To study the mechanism of Yishen Shengxue Tablet (YSSXT) in treating aplastic anemia. Methods: Observing the effect of YSSXT on hematopoietic, immunologic, anti infection and body resistance of model mice of aplastic anemia. Results: YSSXT had marked effect of promotion on recovering myleran injury induced reduction of colony forming unit spleen (CFU S), colony forming unit culture (CFU C), colony forming unit erythrocyte (CFU E), markedly promoting the peritoneal macrophage phagocytosis of normal mice, also markedly lower the mortality of Staphylococcus aureus inoculated mice, and elevate the anoxia resistant ability under normal pressure of anoxic mice, prolonging their survival time. Conclusion: Using YSSXT to treat aplastic anemia that the effectiveness might be realized through promoting the proliferation of hematopoietic stem cells of bone marrow, enhancing the non specific immunity, and the anti infectionn as well as body resistance.

关 键 词：益肾生血片 再生障碍性贫血 中医药疗法 

分 类 号：R259.565[医药卫生—中西医结合]