虎杖提取物对CCl_4诱导的小鼠急性肝损伤的保护作用  

Effect of Polygonum cuspidatum extract on CCl_4-induced acute liver injury in mice

作　　者：鲍琛 

机构地区：[1]浙江宁海县第一医院,宁海315600

出　　处：《海峡药学》2010年第6期36-38,共3页Strait Pharmaceutical Journal

摘　　要：目的观察虎杖提取物对CCl4诱导的小鼠急性肝损伤的保护作用。方法采用CCl4诱导小鼠急性肝损伤模型,测定血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、肝组织超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果 CCl4诱导的小鼠急性肝损伤模型,血清ALT、AST明显升高,肝组织SOD活性明显降低,MDA含量显著升高(P<0.01);虎杖提取物能显著降低血清ALT,AST,明显提高肝组织SOD活性,降低肝组织MDA含量(P<0.01)。结论虎杖提取物具有降酶及抗氧化的作用,对CCl4诱导的小鼠急性肝损伤具有一定的保护作用。OBJECTIVE To observe the Polygonum cuspidatum extract on CCl4induced acute liver injury in mice.METHODS CCl4-induced acute liver injury model in mice,determine serum alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,liver superoxide dismutase（SOD） activity and malondialdehyde（MDA） content in liver tissue.RESULTS CCl4-induced acute liver injury model in mice,serum ALT,AST significantly increased,liver SOD activity was significantly reduced,MDA levels were significantly increased（P0.01）;Polygonum cuspidatum extrat can significantly reduce serum ALT,AST,obviously improve liver SOD activity and lower MDA content in liver tissue（P0.01）.CONCLUSION Polygonum cuspidatum extract has lower liver enzymes and anti-oxidation effect on the CCl4-induced acute liver injury in mice have some protective effect.

关 键 词：虎杖 四氯化碳 肝损伤 降酶 抗氧化 

分 类 号：R969[医药卫生—药理学]