增食欲素调节下丘脑-垂体-肾上腺轴的研究进展  

Recent progress of orexin in the regulation of the hypothalamic-pituitary-adrenal axis

作　　者：王露[1] 赵玉岩[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,沈阳110001

出　　处：《国际内分泌代谢杂志》2010年第B04期22-25,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30872724）;辽宁省教育厅自然科学基金资助项目（20082116）

摘　　要：增食欲素A和增食欲素B是下丘脑神经肽，通过激活两种G蛋白耦联受体发挥作用。增食欲素及其受体表达于下丘脑室旁核和正中隆起，增食欲素受体还表达于脑垂体促皮质激素细胞、肾上腺皮质和髓质。增食欲素能调节摄食、能量代谢平衡、睡醒周期、血压等，还能调节下丘脑-垂体-肾上腺（HPA）轴。现就增食欲素及其受体在HPA轴中枢支和周围支（peripheral branches）的表达及作用机制作一综述。Orexin A and orexin B are bypothalamic peptides that play roles via two G protein-coupled receptors. Orexins and their receptors are expressed in the hypothalamic paraventricular nucleus and median eminence, orexins receptors also expressed in pituitary corticotrophs, adrenal cortex and medulla. Orexins regulate feeding, energy metabolic homeostasis, the sleep/wake cycle, blood pressure and so on, they also modulate the hypothalamic-pituitary-adrenal （HPA） axis. Expression and function of orexins and their receptors in the central and peripheral branches of the HPA axis are reviewed in this article.

关 键 词：增食欲素 增食欲素受体 下丘脑-垂体-肾上腺轴 

分 类 号：R285.5[医药卫生—中药学]