网膜素与肥胖及胰岛素抵抗的关系  

Relationship between omentin and obesity, insulin resistance

作　　者：张涛[1] 田林红[1] 张明[1] 王春玲[1] 

机构地区：[1]兰州大学第二医院内分泌科,730030

出　　处：《国际内分泌代谢杂志》2010年第B04期31-33,共3页International Journal of Endocrinology and Metabolism

基　　金：甘肃省科学技术攻关计划项目（0708NKCA099）

摘　　要：网膜素是新近发现的一种脂肪细胞因子，特异性表达于内脏脂肪组织。目前研究表明，网膜素能促进皮下和网膜脂肪细胞胰岛素刺激的葡萄糖转运和蛋白激酶B磷酸化，且与肥胖相关，在调节糖代谢中具有一定作用。因此，对网膜素的表达、作用机制及生物学功能的深入研究，有助于进一步阐明肥胖、代谢综合征及糖尿病等的发病机制．从而为这砦疾病的治疗提供新的方向。Omentin is a novel visceral fat depot-specific adipokine. Current studies have shown that omcntin enhances insulin-stimulated glucose transport and Akt phosphorylation in human subcutaneous as well as visceral adipocytes. It＇s also related to obesity,and play a certain role in the regulation of glucose metabolism. Further study of omentin＇s expression, mechanism and biological functions is benefit for clarifying the pathogenesis of obesity,metabolic syndrome and diabetes, and may provide a new therapeutic direction for these diseases.

关 键 词：网膜素 肥胖 胰岛素抵抗 代谢综合征 

分 类 号：R587.1[医药卫生—内分泌]