过氧化物酶体增殖物活化受体γ与糖脂代谢  

The role of PPARγ on glycolipid metabolism

作　　者：关晓丽[1] 刘一帆[1] 刘怡[1] 陈慧[1] 

机构地区：[1]兰州大学第二医院内分泌科,730030

出　　处：《国际内分泌代谢杂志》2010年第B04期34-36,共3页International Journal of Endocrinology and Metabolism

摘　　要：过氧化物酶体增殖物活化受体（PPAR）属于核受体超家族一员，与其他甾体类激素受体一样，也是配体激活的转录因子。2型糖尿病与肥胖等代谢性疾病严重影响人类的健康，噻唑烷二酮类（TZDs）药物作为PPAR的激动剂，在脂肪细胞分化、糖脂代谢、胰岛素抵抗中起重要作用。PPAR的常见基因多态性与2型糖尿病、肥胖、脂代谢异常等有关，现仅就PPARγ与糖脂代谢的关系综述如下。Peroxisome proliferator-activated receptor （PPAR） belongs to the nuclear receptor superfamily, and like other steroid hormone receptors, it is also ligand-activated transcription factor. Type 2 diabetes and metabolic diseases such as obesity seriously affect human health, thiazolidinediones （TZDs） as PPAR agonists ,plays important roles in adipocyte differentiation, glucose and lipid metabolism, insulin resistance. Gene polymorphisms of PPAR are associated with type 2 diabetes, obesity, abnormal lipid metabolism. This article reviews the relationship between PPARγ and glycolipid metabolism.

关 键 词：过氧化物酶体增殖物活化受体 代谢性疾病 基因多态性 

分 类 号：R544.1[医药卫生—心血管疾病]