心肌营养素-1与糖尿病心肌病  

Cardiotrophin-1 and diabetic cardiomyopathy

作　　者：王春玲[1] 田林红[1] 张涛[1] 

机构地区：[1]兰州大学第二医院内分泌科,730030

出　　处：《国际内分泌代谢杂志》2010年第B04期47-49,共3页International Journal of Endocrinology and Metabolism

基　　金：甘肃省科技厅-技术研究与开发专项计划资助项目（0805TCYA046）

摘　　要：心肌营养素-1（CT-1）是从小鼠胚胎干细胞中克隆出的一种细胞因子，为白细胞介素-6细胞因子家族的新成员。CT-1可通过促进心肌细胞肥大、成纤维细胞的生长及胶原的合成，参与和调节心室肥厚及重构。糖尿病心肌病的病理生理过程中存存心肌重构，且2型糖尿病患者血浆中CT-1水平升高，表明CT-1可能在糖尿病心肌病的发生、发展中起重要的调节作用。确切的机制尚不清楚，可能与促进心肌重构有关。Cardiotrophin-1 （ CT-1 ） was found from the mouse embryonic stem cell elone. It is a new cytokine in interleukin-6 family. CT-1 participates in and regulates ventricular hypertrophy and ventricular remodeling by promoting myocardial hypertrophy, the growth of fibroblasts and collagen synthesis. Cardiac remodeling exists in the pathophysiological process of diabetic eardiomyopathy. Also the elevation of plasma CT-1 in diabetic patients indicates that CT-1 may play an important role in the regulation of diabetic cardiomyopathy. The exact mechanism is not clear yet,may be related to the promotion of cardiac remodeling.

关 键 词：心肌营养素-1 糖尿病心肌病 心室重构 血管紧张素Ⅱ 

分 类 号：R542.2[医药卫生—心血管疾病]