哨兵淋巴结活检对乳腺癌腋窝淋巴结转移的预测  

Prediction of sentinel lymph node biopsy for axillary lymph node metastasis in breast cancer

作　　者：梁峰[1] 张宏艳[2] 陈济生[1] 刘莎[1] 尉承泽[1] 王钢乐[1] 

机构地区：[1]军事医学科学院附属医院普外科,北京100071 [2]北京军区总医院肿瘤科,北京100700

出　　处：《中国现代医学杂志》2010年第11期1698-1700,共3页China Journal of Modern Medicine

摘　　要：目的探讨前哨淋巴结(SLN)活检术(SLNB)对乳腺癌腋窝淋巴结转移的预测意义。方法对2000年11月～2003年10月的179例临床T1～3N0M0期乳腺癌患者用美蓝注射于乳腺癌肿瘤瘤周后,进行SLNB,随后所有病例均行包括腋窝淋巴结清扫术在内的乳腺癌手术切除。结果成功检出前哨淋巴结171例,检出成功率为95.5%(171/179)。SLN检出1个者70例,占40.9%;2个者56例,占32.7%;3个以上者45例,占26.3%。SLNB的准确性为88.9%,灵敏度87.7%,特异度89.8%,假阴性率12.3%(9/73)。原发肿瘤大小、腋窝淋巴结转移数目与假阴性率有关,原发肿瘤大于2cm,腋窝淋巴结转移1～3个时易出现假阴性。结论 SLN转移情况基本能够预测乳腺癌腋窝淋巴结转移的状况。[Objective]To study significance of sentinel lymph node （SLN） biopsy （SLNB） in the prediction of axillary lymph node metastasis in breast cancer. [Methods] Between Nov 2000 and Oct 2003, sentinel lymph nodes of 179 patients with T1～3N0M0 breast cancer injected by methylenc blue staining were excised for biopsy, patients then received operations for breast cancer including axillary dissection. [Results]SLN was identified in 171 patients, the identification rate was 95.5 %（171/179）. The total number of SLN identified was one in 70 cases （40.9%）, 2 in 56 cases （32.7%）, and≥3 in 45 cases （26.3%）. The accuracy rate, sensitivity and specificity were 88.9%, 87.7%, 89.8%, the false negative rate was 12.3% （9/73）. The tumor size and positive numbers of axillary lymph node were relation factor of false negative.[Conclusion]The SLN status can generally be a representation of axillary metastasis, SLNB is useful to predict the status of axillary lymph node of breast cancer patients.

关 键 词：乳腺肿瘤 前哨淋巴结活检 淋巴转移 活组织检查 

分 类 号：R605[医药卫生—外科学] R737.9[医药卫生—临床医学]