短期胰岛素泵强化治疗对新诊断2型糖尿病患者胰岛素抵抗的影响  

Effect of short-term insulin pump intensive therapy in patients with newly diagnosed type 2 diabetes mellitus insulin resistance

作　　者：范玉仙[1] 李彩凤[1] 吕律森 

机构地区：[1]河北省保定市第一中心医院内分泌科,河北保定071000

出　　处：《中国现代医学杂志》2010年第11期1718-1720,共3页China Journal of Modern Medicine

摘　　要：目的探讨短期胰岛素泵强化治疗对新诊断2型糖尿病患者胰岛素抵抗的影响。方法选择该院2007～2008年46例新诊断2型糖尿病患者,采用短期胰岛素泵强化治疗。患者进行2周持续性胰岛素皮下输注(CSII)治疗,观察并记录治疗前后患者的空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素分泌指数(Homa-β)及胰岛素抵抗指数(Homa-IR)。结果治疗后患者的FINS、Homa-β均明显升高,FPG、Homa-IR均明显较低,差异均有统计学意义(P<0.05或P<0.01)。结论短期胰岛素泵强化治疗新诊断2型糖尿病患者,能够明显控制血糖,改善胰岛β细胞,降低胰岛素抵抗作用。[Objective]To explore the effect of short-term insulin pump intensive therapy in patients with newly diagnosed type 2 diabetes mellitus insulin resistance. [Methods]From 2007 to 2008 in our hospital, 46 cases of newly diagnosed type 2 diabetes treated with short-term insulin pump intensive therapy were selected, treated by continuous subcutaneous insulin infusion （CSⅡ） treatment for two weeks. The fasting plasma glucose （FPG） , fasting insulin （FINS）, insulin secretion index （Homa-β） and insulin resistance index （Homa-IR） were observed and recorded before and after treatment in patients.[Results]After treatment in patients with FINS, Homa-β were significantly higher, FPG, Homa-IR were significantly lower, the differences were statistically significant （P 0.05 or P 0.01）. [Conclusion]Short-term insulin pump intensive therapy in patients with newly diagnosed type 2 diabetes mellitus can significantly improve the islet β cells and reduce insulin resistance.

关 键 词：2型糖尿病 胰岛素抵抗 短期胰岛素泵 强化治疗 

分 类 号：R587.1[医药卫生—内分泌]