鲍曼不动杆菌医院感染分布特征及耐药性分析  

Characteristics of Clinical Distribution and Antimicrobial Resistance of Acinetobacter Baumannii

作　　者：汤桂丽[1] 

机构地区：[1]中国人民解放军成都军区第324医院检验科,重庆400020

出　　处：《中国药业》2010年第12期27-28,共2页China Pharmaceuticals

摘　　要：目的研究鲍曼不动杆菌的医院感染分布特征及其对常见抗生素的耐药性。方法采用回顾性方法统计分析206株鲍曼不动杆菌的标本来源、感染科室分布及耐药状况。结果 206株鲍曼不动杆菌中,来自痰液154株(74.76%),来源于咽拭子18株(8.74%)及伤口分泌物15株(7.28%);感染科室分别为呼吸内科64株(31.07%),重症监护病房(ICU)35株(16.99%),血液内科30株(14.56%)。药物敏感试验结果显示,鲍曼不动杆菌对β-内酰胺类、氨基苷类、喹诺酮类均有较高的耐药性,而对碳青酶烯类、β-内酰胺类及含酶抑制剂复合药物较敏感,其中最敏感的是亚胺培南(91.8%),其次是美罗培南(84.5%)。结论鲍曼不动杆菌临床分离株多来自于痰液标本和呼吸科病房,对多种抗菌药物的耐药率较高,临床应加强对鲍曼不动杆菌耐药性的监控并防治耐药菌株的传播流行。Objective To investigate the distribution and drug resistance of clinical Acinetobacter baumannil isolates（ABI） in nosocomial infections.Methods A retrospective method was employed to analyze the specimen sources,distribution of departments and drug resistance of 206 isolates of Acinetobacter baumannil.Results Among the 206 isolates,154 strains（74.76%） came from sputum,18 strains（8.74%） from throat swab and 15 strains（7.28%） from wound secretion respectively.The distribution of ABI in the respiratory department,ICU and the hemotologic department were 64 strains（31.07%）,35 strains（16.99%） and 30 strains（14.56%）,respectively.Acinetobacter baumannil was resist to β-lactam,aminoglycosides and fluoroquinolones antibiotics,but sensitive to carbapermen and β-lactamases,most sensitive to imipenem（91.8%） and meropenem（84.5%）,respectively.Conclusion Clinical isolates of Acinetobacter baumannil comes mainly from the sputum and respiratory department and its resistant rates are rather high.We should pay more attention to the surveillance of antimicrobial resistance of Acinetobacter baumannil in clinic for preventing transmission and epidemic of the resistance strains.

关 键 词：鲍曼不动杆菌 耐药性 抗菌药物 分布特征 

分 类 号：R915[医药卫生—微生物与生化药学] R969.3[医药卫生—药学]