氧化低密度脂蛋白、高敏C反应蛋白与冠状动脉支架置入术后再狭窄的关系  

Relationship between plasma level of ox-LDL,hs-CRP and the development of in stent restenosis

作　　者：刘晓红 洪苍浩 汤国法 李裕舒[2] 

机构地区：[1]鄂州市鄂钢医院心内科,湖北鄂州436000 [2]华中科技大学协和医院心内科

出　　处：《临床心血管病杂志》2010年第5期326-328,共3页Journal of Clinical Cardiology

摘　　要：目的：探讨氧化低密度脂蛋白（ox-LDL）、高敏C反应蛋白（hs-CRP）与经皮冠状动脉介入治疗（PCI）术后支架内再狭窄的相关性。方法：45例患者PCI术后6~12个月内接受冠状动脉造影复查,其中18例有再狭窄作为再狭窄组,27例无再狭窄作为对照组。2组术后均接受阿司匹林、波立维、他汀类等药物治疗。取2组患者PCI术前、后冠状动脉造影复查时血浆标本,采用酶联免疫吸附法（ELISA）检测血浆ox-LDL水平,超敏免疫比浊法检测血浆hs-CRP水平,酶法测定血脂水平。结果：①再狭窄组PCI术后ox-LDL、hs-CRP水平较术前均明显升高[（1.32±0.35）∶（0.53±0.17）mg/L、（4.82±1.44）∶（3.50±1.18）mg/L],均P〈0.01;对照组PCI后ox-LDL、hs-CRP水平较术前明显下降[（0.32±0.13）∶（0.55±0.13）mg/L、（2.28±0.71）∶（3.37±1.25）mg/L],均P〈0.05。②再狭窄组和对照组PCI术前ox-LDL、hs-CRP水平差异无统计学意义,再狭窄组PCI术后ox-LDL、hs-CRP水平显著高于对照组（均P〈0.01）。③再狭窄组和对照组术后TC、TG、LDL-C水平均较术前明显下降（P〈0.05）,但2组间PCI术前和术后比较均差异无统计学意义（P〉0.05）。④再狭窄组和对照组术前、术后ox-LDL和hs-CRP水平均呈正相关。结论：PCI术后再狭窄患者血浆ox-LDL及CRP水平明显升高,二者可作为PCI术后再狭窄的预测指标。Objective：To investigate the relationship between plasma level of oxidized low density lipoprotein（ox-LDL）,high sensitivity C-reactive protein（hs-CRP） and the development of in stent restenosis.Method：Forty-five patients with successfully coronary stent implantation followed by coronary angiography within 6-12 months after PCI were enrolled.patients with restenosis（n=18） were assigned in restenosis group,and 27 patients in control group.Blood plasma levels of ox-LDL and hs-CRP were analysed in all cases before PCI and after PCI within 6-12 months.Plasma ox-LDL were measured by ELISA,and plasma hs-CRP were asseyed by immunoturbidimetry.Result：Blood plasma levels of ox-LDL and hs-CRP were significantly higher than those before PCI in restenosis group（P〈0.01）.The biomarkers were significantly lower than those before PCI in control group（P〈0.01）.There was no significantly difference of ox-LDL and hs-CRP levels between restenosis group and control group before PCI,but they were significantly higher in restenosis group than in control group after PCI（P〈0.01）.There was a positive correlation between plasma levels of ox-LDL and hs-CRP in restenosis group as well as in control group before and after PCI.Conclusion：Both ox-LDL and hs-CRP may be regarded as prognostic indicators in patients developing restenosis after coronary stenting.

关 键 词：血管成形术 经腔 经皮冠状动脉 氧化低密度脂蛋白 高敏C-反应蛋白 再狭窄 

分 类 号：R654.3[医药卫生—外科学]