肺心病患者红细胞膜脂质过氧化作用与红细胞免疫功能之间的关系  

Relationship between peroxidation in erythrocyte membraneand and red cell immune function in cor pulmonale subjects

作　　者：姜永堂[1] 陈学魁[1] 安继红[1] 赫国志[1] 

机构地区：[1]长春白求恩医科大学二院呼吸内科

出　　处：《中国免疫学杂志》1999年第1期42-43,共2页Chinese Journal of Immunology

基　　金：吉林省科委资助课题

摘　　要：目的：探讨肺心病患者脂质过氧化对红细胞免疫功能的影响。方法：采用红细胞酵母菌混合花环法和硫代巴比土酸（ＴＢＡ）法检测了肺心病患者红细胞Ｃ３ｂ受体、血浆及红细胞膜丙二醛（ＭＤＡ）水平。结果：肺心病患者红细胞Ｃ３ｂ受体明显降低；血浆ＭＤＡ和红细胞膜ＭＤＡ明显升高；在急性期肺心病患者上述变化更为显著，同时伴有红细胞免疫复合物花环率降低；红细胞Ｃ３ｂ受体和血浆ＭＤＡ及红细胞膜ＭＤＡ呈负相关，多元逐步回归分析膜ＭＤＡ和Ｃ３ｂ受体降低关系更为密切。Objective:To evaluate the relationship between peroxidation in erythrocyte membrane and red cell immune function in cor pulaonale.Methods:The red cell immune function and the levels of malonyldialdehyde(MDA) in plasm and erythrocyte membrane were tested by red cell yeast mixture rose and thiobarbituric acid(TBA) methods.Results:The levels of erythrocyte C 3b receptor was significantly decreased in acute stage cor pulmonale( P <0 01).The levels of plasma and erythrocyte membrane MDA in cor pulmonale were higher than those in healthy( P <0 01).Conclusion:The results indicated that lipid peroxidation,particularly in erythrocyte membrane,might contribute to the decrease of erythrocyte of receptor.

关 键 词：肺心病 红细胞 免疫功能 脂质过氧化 丙二醛 

分 类 号：R541.502[医药卫生—心血管疾病]