心肌细胞凋亡信号传导通路与心肌损伤  

Myocytes apoptosis signal transduction pathways and the myocardium injury

作　　者：戴日新[1] 李浪[1] 

机构地区：[1]广西医科大学第一附属医院心内科广西心血管病研究所,广西南宁530021

出　　处：《基础医学与临床》2010年第7期775-777,共3页Basic and Clinical Medicine

基　　金：国家自然科学基金(C030313)

摘　　要：在心肌损伤中,心肌细胞凋亡信号通路包括了依赖于caspase的信号途径和不依赖于caspase的信号途径,以及炎性反应、氧化及自噬等信号机制的交联和激活信号途径,心肌细胞的凋亡信号通路决定着心肌的生存与死亡,对心肌损伤的发生、发展及预后产生重要影响。The cardiac myocyte apoptosis signal transduction includes caspase-dependend pathways and caspase-independend pathway,and also involve crosstalk or interaction with the inflammation,oxidation stress,autophagy and other mechanisms signal networks in myocardium injury.The apoptotic signaling pathway control the life cycle of cardiac myocyte in the heart.It has a great impact on the development and prognosis of the myocardium injury.

关 键 词：信号传导 凋亡 心肌细胞 心肌损伤 

分 类 号：R541[医药卫生—心血管疾病]