特发性血小板减少性紫癜与人细小病毒B19感染的关系  

Relationship between human parovirous B19 infection and idiopathic thrombocytopenic purpura

作　　者：张笑飞[1] 许东亮[1] 张国成[1] 钱新宏[1] 王瑞华[1] 

机构地区：[1]第四军医大学西京医院

出　　处：《中华儿科杂志》1999年第1期15-17,共3页Chinese Journal of Pediatrics

摘　　要：目的研究人细小病毒Ｂ１９（ＨＰＶＢ１９）感染与特发性血小板减少性紫癜（ＩＴＰ）的关系。方法应用巢式聚合酶链反应技术检测８４例ＩＴＰ患儿存档骨髓涂片标本中ＨＰＶＢ１９ＤＮＡ，并以２４例巨幼细胞性贫血（ＭＡ）患儿为对照。结果８４例ＩＴＰ骨髓中ＨＰＶＢ１９ＤＮＡ阳性３６例，阳性率为４３％，２４例ＭＡ患儿骨髓中ＨＰＶＢ１９ＤＮＡ阳性３例，阳性率为１２％，（χ２＝６．１９９，Ｐ＜０．０５），ＩＴＰ组中首发和复发，治疗前与治疗后以及不同性别患儿骨髓中ＨＰＶＢ１９ＤＮＡ检出率均无明显差异，急性型与慢性型ＩＴＰ患儿骨髓中ＨＰＶＢ１９ＤＮＡ检出率之间有差异。结论临床上较大部分ＩＴＰ患儿的发病可能与ＨＰＶＢ１９感染有关；急性型ＨＰＶＢ１９ＤＮＡ检出率高。Objective To study the relationship between human parovirus B19(HPV B19) infection and idiopathic thrombocytopenic purpura (ITP). Methods Nested polymerase chain reaction was used to detect HPV B19 DNA on stock bone marrow smears from 84 children with ITP. Twenty four cases of macrocytic anemia (MA) were chosen as controls. Results Thirty six of 84 cases of ITP and 3 of 24 cases of MA were positive for HPV B19 DNA, with a positive rates of 43% and 12%, respectively ( χ 2=6.199, P <0.05). There were no differences in the HPV B19 DNA detective rates concerned with the onset and recurrence of ITP, treatment, and genders. However, there was a significant difference in detective rates between different stages of ITP (acute stage vs. chronic stage). Conclusion Most attacks of ITP might be correlated with HPV B19 infection. The higher detective rates of HPV B19 were found in the younger patients with ITP and in acute stage of ITP. However, the HPV B19 DNA detective rate was not correlated with the genders, treatement, as well as the onset and recurrence of ITP.

关 键 词：细小病毒B19 聚合酶链反应 紫癜 血小板减少性 

分 类 号：R554.602[医药卫生—血液循环系统疾病] R373.9[医药卫生—内科学]