硒拮抗砷致小鼠微核率改变的剂量效应特征  

Characterization of antagonism of selenium against arsenic induced micronuclei in mice

作　　者：李金有[1,2] 刘志艳[1,2] 孙天佑 李贵明[1,2] 

机构地区：[1]山西医科大学劳卫教研室 [2]山西医科大学法医系

出　　处：《中国地方病学杂志》1999年第1期5-6,共2页Chinese Jouranl of Endemiology

基　　金：山西省教委青年学科带头人培养基金

摘　　要：目的明确硒拮抗砷致小鼠微核变化的可行性及剂量特征。方法小鼠骨髓微核试验。结果与对照组相比，染硒同时染砷，硒可明显地拮抗砷诱发小鼠微核变化的作用，且呈剂量－反应关系。结论硒对砷致小鼠微核变化具有拮抗作用；Objective To clearify the fesibility of antagonism of selenium against arsenic induced micronuclei in mice and its dose characteristics.Methods Bone Marrow Micronuclei (BMM) assay in mice was used.Results In comparesion with control group,coexposure of selenium and arsenic to mice could induce a dose effect antagonism of selenium against arsenic induced micronuclei in mice.Conclusions Selenium can antagonize the arsenic induced micronuclei in mice and this gurrantee a scientific evidence for both further study and field intervention of selenium against arsenic toxity

关 键 词：硒 骨髓微核 拮抗作用 砷中毒 小鼠 

分 类 号：R595.2[医药卫生—内科学]