白芍总苷对接触性皮炎小鼠核因子-κB、CD1a因子、肿瘤坏死因子的影响  

Effects of total glucosides of paeony on murine allergic contact dermatitis

作　　者：陈菲菲[1,2] 朱晓芳 高慧 骆丹[1] 

机构地区：[1]南京医科大学第一临床医学院,江苏南京210009 [2]扬州大学临床医学院皮肤科,江苏扬州225001

出　　处：《实用临床医药杂志》2010年第6期5-7,16,共4页Journal of Clinical Medicine in Practice

基　　金：江苏省扬州市科技攻关资助项目(YZ2008041)

摘　　要：目的探讨白芍总苷对小鼠变应性接触性皮炎(ACD)的治疗作用。方法以2,4-二硝基氟苯(DNFB)对小鼠进行皮肤致敏及激发,制成小鼠接触性皮炎模型,观察白芍总苷对小鼠耳肿胀度、组织病理改变及皮损处核因子-κB(NF-κB)、CD1a因子表达及血清肿瘤坏死因子(TNF-α)水平的影响。结果白芍总苷能显著抑制ACD小鼠的耳肿胀度,可降低诱发后的小鼠血清TNF-α水平,下调NF-κB、CD1a的表达。结论白芍总苷对小鼠ACD有治疗作用,这与其下调炎性细胞因子水平有关,也可能与下调NF-κB、CD1a的表达有关。Objective To study the effects and mechanisms of Total Glucosides of Paeony on murine allergic contact dermatitis（ACD）.Methods The murine model of ACD induced by 2,4-dinitrofluorobenzene（DNFB）was established.Observe the effect of Total Glucosides of Paeony（TGP）on murine ear swelling,histopathological changes,the levels of NF-κB、CD1a by immunohistochemical method and the levels of serum TNF-α.Results Murine ear swellings were suppressed by TGP,and TGP could down-regulate the level of serum TNF-αand the expressions of NF-κB、CD1a in skin lesions.Conclusion TGP has therapeutic effects on murine ACD,which is probably related to the down-regulation of the expressions of cytokines and alsothe expressions of NF-κB and CD1a.

关 键 词：白芍总苷 接触性皮炎 肿瘤坏死因子(TNF-α) 核因子-κB(NF-κB) CD1A 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]