痰热清注射液对创伤性急性肺损伤患者细胞因子表达的影响  

Effect of Tanreqing Injection on the Cytokine Expression of Traumatic Acute Lung Injury

作　　者：阳世雄[1] 赵永亮[1] 曾建业[1] 韦涌初[1] 黄思光[1] 卢苇[1] 

机构地区：[1]广西医科大学第三附属医院,南宁530031

出　　处：《中国中医急症》2010年第7期1087-1088,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：广西壮族自治区医疗卫生自筹经费计划课题(No.Z200844)

摘　　要：目的观察痰热清注射液对创伤性急性肺损伤患者血清细胞因子的影响。方法将59例创伤性急性肺损伤患者随机分为治疗组(29例)和对照组(30例),两组均予西医常规治疗,治疗组加用痰热清注射液静滴。比较治疗前后两组患者血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)的变化;比较两组患者ARDS的发病率和死亡率的差异。结果治疗7d后治疗组较对照组血清IL-6、IL-8、TNF-α水平降低;两组ARDS的发病率和病死率相近。结论痰热清注射液能降低血清TNF-α、IL-6、IL-8炎性因子的水平,缓解炎性反应综合症的进展。Objective：To observe the effect of Tanreqing Injection on the cytokines expression of traumatic acute lung injury patients. Methods：59 patients were randomly divided into two groups with routine therapy. Meanwhile,the treatment group was added the Tanreqing Injection. There were some indices compared before and after treatment including the serum interleukin-6（IL-6） ,the interleukin-8（IL-8） and the tumor necrosis factor-α（TNF-α） . And then,the incidence and the mortality were also compared between two groups. Results：After 7 days treatment,the IL-6,the IL-8 and the TNF-α of the treatment group were lower than those of the control group. Nevertheless,there were no significant differences between two groups including the incident and the mortality. Conclusion：Tanreqing Injection could relieve the progress of systemic inflammation response syndrome through decreasing levels of the IL-6,the IL-8 and the TNF-α.

关 键 词：创伤性急性肺损伤 细胞因子 痰热清注射液 

分 类 号：R641[医药卫生—外科学]