降钙素原（PCT），hs—CRP及血培养在新生儿败血症诊断中的应用价值  

Application of hs-CRP,PCT and Blood Culture in Neonatal Sepsis

作　　者：曹三成[1] 祝撷英[1] 贾凯[1] 梁西强[1] 徐蓓[1] 王娟[1] 陈则莲[1] 

机构地区：[1]西安市儿童医院检验科,西安710003

出　　处：《现代检验医学杂志》2010年第3期82-83,共2页Journal of Modern Laboratory Medicine

摘　　要：目的探讨血清降钙素原（PCT）、超敏C-反应蛋白（hS-CRP）及血培养在新生儿败血症确定诊断中的应用价值。方法采用免疫色谱法、免疫比浊法、血培养分别检测93例临床诊断为新生儿败血症血液中的PCT，hs—CRP，细菌阳性率。结果PCT阳性率95．69％（正常参考值〈0．5ng／m1）。hs—CRP阳性率91．4％（正常参考值0～3mg／L），血培养阳性率60．22％。PCT阳性率高于血培养阳性率（Х^2=31．03，P〈0．05），hs-CRP阳性率高于血培养阳性率（Х^2=25．29，P〈0．05），PCT阳性卒与hs—CRP阳性率比较差畀无统计学意义（Х^2=1．5，P〉0．05）。结论血清PCT，hs—CRP可作为新生儿败血症确定诊断的检测指标，都具有比血培养更高的诊断价值，在做血培养的同时，应尽早开展PCT和hs—CRP检测。Objective This study aimed to investigate the application of serum procalcitonin （PCT）,high-sensitivity C-reactive protein （hs-CRP） and blood culture in definite diagnosis of neonatal sepsis. Methods The level of serum PCT and hs- CRP in blood samples of 93 newborns with clinical sepsis were measured by semi-quantitative solid-phase immune chromatography and immune turbidimetry respectively. The positive rate of bacteria in blood samples were also analysed by blood culture. Results The positive rate of serum PCT （Normal limits of PCT〈0. 5 ng/ml） and hs-CRP （Normal limits of hs-CRP 〈3mg/L） in blood samples were 95.69% and 91.4% respectively,while the positive rate of bacteria was 60. 22% by blood culture. Blood culture had significant differences in positive detection rate compared with serum PCT（Х^2=31.03,P〈0.05） and hs-CRP （Х^2= 25.29,P〈0. 05）,while serum PCT had no significant difference compared with hs- CRP in positive detection rate（Х^2=l. 5,P〉0. 05）. Conclusion Serum PCT and bs-CRP which have more important diagnostic value compared with blood culture,could be used as important indexes in the definite diagnosis of neonatal sepsis, and should be combined with blood culture in early diagnosis of neonatal sepsis.

关 键 词：降钙素原(PCT) 超敏C-反应蛋白(hs—CRP) 血培养 新生儿败血症 

分 类 号：R515.3[医药卫生—内科学] R392.11[医药卫生—临床医学]