血压正常高值人群尿酸现状及相关因素分析  

Analysis on serum uric acid and relating cardiovascular factors in prehypertension.

作　　者：刘敏[1] 陈新云[1] 刘锐[2] 秦方[1] 闫亚非[1] 唐丹[1] 伍悦蕾[1] 叶小平[1] 姚园媛[1] 余波 左建春 刘建 

机构地区：[1]成都市第一人民医院心内科,四川成都610041 [2]成都理工大学信息管理学院,四川成都610059 [3]成都市石羊社区卫生服务中心,四川成都610041 [4]成都双流县卫生服务中心,四川成都610200 [5]成都市成华区卫生服务中心,四川成都610000

出　　处：《四川医学》2010年第6期704-705,共2页Sichuan Medical Journal

基　　金：成都市十一五重大专项资助课题(编号:08YTB931SF-020)

摘　　要：目的探讨正常血压人群与血压正常高值人群尿酸水平,高尿酸血症患病率及相关心血管事件危险因素的比较。方法采取整群分级抽样方法调查成都市3个社区3524例社区居民血压水平及尿酸等代谢指标,按不同的血压水平分为正常血压组和血压正常高值组,分别比较两组间血尿酸浓度水平、高尿酸血症的患病率及相关心血管事件危险因素差异,并就血压与尿酸及相关代谢指标做相关分析。结果血压正常高值组比正常血压组的血尿酸水平高[(302.91±81.89)μmol/L vs(284.78±78.56)μmol/L,P<0.001],高尿酸血症的患病率在血压正常高值组为8.7%,高于血压正常组4.4%(P=0.002),血压正常高值组的年龄、BMI、血脂、心率、血糖等指标比正常血压组高,差异均有统计学意义。血压与各危险因素的相关性分析显示,收缩压和舒张压与年龄,BMI、尿酸、心率有弱相关,与胆固醇有强相关。结论血压正常高值人群比正常血压人群有着更高的包括高尿酸血症在内的心血管危险因素。Objective The prevalence of serum uric acid and hyperuricemia,as well as cardiovascular risk factors,was assessed in prehypertensive subjects and normotensive subjects.Methods Randomly cluser sampling was carried on 3524 residents in 3 districts in Chengdu.the BP level and metabolize indexes,such as uric acid,was investigated.Blood pressure was categorized as prehypertension and normotension,we assessed serum uric acid,hyperuricemia and relating cardiovascular risk factors between the two groups.Results Prehypertensive subjects had higher uric acid levels than normotensive subjects[（302.91±81.89）μmol/L vs（284.78±78.56）μ mol/L,P0.001],Hyperuricemia was found in 8.7% of prehypertensive subjects and in 4.4% of normotensive subjects（P=0.002）,the indexes like age,BMI,serum glucose,heart rate and lipid in prehypertensive subjects were higher than those in normotensive subjects.Multiple logistic regression analysis suggested systolic pressure and diastolic pressure both co-existed with age,BMI,uric acid,heart rate and cholesterol.Conclusion Prehypertensive subjects have greater risk factors for cardiovascular disease,including hyperuricemia,than normotensive subjects.

关 键 词：血压正常高值 高尿酸血症 尿酸 

分 类 号：R544.1[医药卫生—心血管疾病] R589.7[医药卫生—内科学]