充血性心力衰竭患者甲状腺激素和可溶性白细胞介素-2受体变化的研究  

Study on the changes of thyroid hormone and soluble interleukin 2 receptor in patients with congestive heart failure

作　　者：赵铁强[1,2] 崔林[1,2] 孟繁超[1,2] 祁晓红[1,2] 李利平 黄永麟[1,2] 

机构地区：[1]哈尔滨医科大学第一临床医学院心内科 [2]哈尔滨医科大学第二临床医学院心内科

出　　处：《中国急救医学》1999年第1期18-19,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的探讨充血性心力衰竭患者甲状腺激素可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）的变化及意义。方法以６８例心力衰竭患者和６０例健康成人为研究对象，用放射免疫分析法和酶标双抗体夹心法分别测定甲状腺激素和ｓＩＬ－２Ｒ，用二维超声心动图测定射血分数（ＥＦ）和心脏指数（ＣＩ）。结果（１）在心衰各组，血清游离三碘甲腺原氨酸（ＦＴ３）显著下降，反Ｔ３（ｒＴ３）显著升高，二者变化与心功能相关而与病因无关；（２）ｓＩＬ－２Ｒ在心衰各组明显高于对照组，ｓＩＬ－２Ｒ与ＥＦ和ＣＩ呈负相关，心功Ⅲ～Ⅳ级患者中扩张型心肌病组ｓＩＬ－２Ｒ的升高程度明显高于风湿性心脏病组和冠心病组（Ｐ＜００１）；（３）ｓＩＬ－２Ｒ与ＦＴ３和ｒＴ３有相关性（γ＝－０５３，γ＝０６７）。结论甲状腺激素和ｓＩＬ－２Ｒ在心衰时有明显改变，二者均参与心衰的发病机制。Objective To investigate the changes and significance of thyroid hormone and soluble interleukin 2 receptor(sIL 2R) in congestive heart failure (CHF) patients. Methods 68 patients with CHF and 60 healthy subjects were chosen for this study. Thyroid hormones were determined with radioimmunoassay and sIL 2R with sandwich enzyme linked immunosorbent assay, ejection fraction (EF) and cardiac index (CI) were measured with twodimensional echocardiographic method. Results (1)In CHF groups FT 3 decreased and rT 3 increased significant, they correlated with EF and CI, but not with cause of CHF;(2)sIL 2R increased obviously in CHF groups, it correlated with the severity of CHF, its level in dilated cardiomyopathy is significantly higher than that in rheumatic heart disease and coronary artery disease( P <0 01);(3)sIL 2R correlated with FT 3 and rT 3 (γ=-0 53,γ=0 67). Conclusion Both thyroid hormone and sIL 2R changed much in CHF patients and they may be involved in the progress of CHF. [

关 键 词：充血性 心力衰竭 甲状腺激素 SIL-2R 

分 类 号：R541.610.2[医药卫生—心血管疾病]